4ehr
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Bcl-Xl complex with 4-(5-butyl-3-(hydroxymethyl)-1-phenyl-1h-pyrazol-4-yl)-3-(3,4-dihydro-2(1h)-isoquinolinylcarbonyl)-n-((2-(trimethylsilyl)ethyl)sulfonyl)benzamide== | |
| + | <StructureSection load='4ehr' size='340' side='right'caption='[[4ehr]], [[Resolution|resolution]] 2.09Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4ehr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EHR FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0Q5:4-[5-BUTYL-3-(HYDROXYMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL]-3-(3,4-DIHYDROISOQUINOLIN-2(1H)-YLCARBONYL)-N-{[2-(TRIMETHYLSILYL)ETHYL]SULFONYL}BENZAMIDE'>0Q5</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ehr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ehr OCA], [https://pdbe.org/4ehr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ehr RCSB], [https://www.ebi.ac.uk/pdbsum/4ehr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ehr ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Banfi P]] | ||
| + | [[Category: Borzilleri RM]] | ||
| + | [[Category: Cai Z]] | ||
| + | [[Category: Galvani A]] | ||
| + | [[Category: Lippy J]] | ||
| + | [[Category: Lombardo LJ]] | ||
| + | [[Category: Menichincheri M]] | ||
| + | [[Category: Modugno M]] | ||
| + | [[Category: Naglich J]] | ||
| + | [[Category: Penhallow B]] | ||
| + | [[Category: Perez HL]] | ||
| + | [[Category: Sack J]] | ||
| + | [[Category: Schmidt RJ]] | ||
| + | [[Category: Schroeder GM]] | ||
| + | [[Category: Tebben A]] | ||
| + | [[Category: Wei D]] | ||
| + | [[Category: Yan C]] | ||
| + | [[Category: Zhang L]] | ||
Current revision
Crystal structure of Bcl-Xl complex with 4-(5-butyl-3-(hydroxymethyl)-1-phenyl-1h-pyrazol-4-yl)-3-(3,4-dihydro-2(1h)-isoquinolinylcarbonyl)-n-((2-(trimethylsilyl)ethyl)sulfonyl)benzamide
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Categories: Homo sapiens | Large Structures | Banfi P | Borzilleri RM | Cai Z | Galvani A | Lippy J | Lombardo LJ | Menichincheri M | Modugno M | Naglich J | Penhallow B | Perez HL | Sack J | Schmidt RJ | Schroeder GM | Tebben A | Wei D | Yan C | Zhang L
