4elh
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure-activity relationship guides enantiomeric preference among potent inhibitors of B. anthracis dihydrofolate reductase== | |
| + | <StructureSection load='4elh' size='340' side='right'caption='[[4elh]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4elh]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis_str._Sterne Bacillus anthracis str. Sterne]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ELH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ELH FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.103Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=53I:(2E)-3-{5-[(2,4-DIAMINOPYRIMIDIN-5-YL)METHYL]-2,3-DIMETHOXYPHENYL}-1-[(1R)-1-(2-METHYLPROP-1-EN-1-YL)PHTHALAZIN-2(1H)-YL]PROP-2-EN-1-ONE'>53I</scene>, <scene name='pdbligand=53J:(2E)-3-{5-[(2,4-DIAMINOPYRIMIDIN-5-YL)METHYL]-2,3-DIMETHOXYPHENYL}-1-[(1S)-1-(2-METHYLPROP-1-EN-1-YL)PHTHALAZIN-2(1H)-YL]PROP-2-EN-1-ONE'>53J</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4elh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4elh OCA], [https://pdbe.org/4elh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4elh RCSB], [https://www.ebi.ac.uk/pdbsum/4elh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4elh ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q81R22_BACAN Q81R22_BACAN] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194] | ||
| - | + | ==See Also== | |
| - | + | *[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Bacillus anthracis str. Sterne]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Barrow WW]] | ||
| + | [[Category: Bourne CR]] | ||
Current revision
Structure-activity relationship guides enantiomeric preference among potent inhibitors of B. anthracis dihydrofolate reductase
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