1l8k

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[[Image:1l8k.jpg|left|200px]]<br /><applet load="1l8k" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1l8k, resolution 2.56&Aring;" />
 
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'''T Cell Protein-Tyrosine Phosphatase Structure'''<br />
 
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==Overview==
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==T Cell Protein-Tyrosine Phosphatase Structure==
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Protein-tyrosine phosphatase 1B (PTP1B) has recently received much, attention as a potential drug target in type 2 diabetes. This has in, particular been spurred by the finding that PTP1B knockout mice show, increased insulin sensitivity and resistance to diet-induced obesity., Surprisingly, the highly homologous T cell protein-tyrosine phosphatase, (TC-PTP) has received much less attention, and no x-ray structure has been, provided. We have previously co-crystallized PTP1B with a number of low, molecular weight inhibitors that inhibit TC-PTP with similar efficiency., Unexpectedly, we were not able to co-crystallize TC-PTP with the same set, of inhibitors. This seems to be due to a multimerization process where, residues 130-132, the DDQ loop, from one molecule is inserted into the, active site of the neighboring molecule, resulting in a continuous string, of interacting TC-PTP molecules. Importantly, despite the high degree of, functional and structural similarity between TC-PTP and PTP1B, we have, been able to identify areas close to the active site that might be, addressed to develop selective inhibitors of each enzyme.
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<StructureSection load='1l8k' size='340' side='right'caption='[[1l8k]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1l8k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L8K FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.56&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l8k OCA], [https://pdbe.org/1l8k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l8k RCSB], [https://www.ebi.ac.uk/pdbsum/1l8k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l8k ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTN2_HUMAN PTN2_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l8/1l8k_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l8k ConSurf].
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<div style="clear:both"></div>
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==Disease==
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==See Also==
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Known diseases associated with this structure: Diabetes mellitus, insulin-dependent, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600716 600716]], Rheumatoid arthritis, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600716 600716]], Systemic lupus erythematosus, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600716 600716]]
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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1L8K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8K OCA].
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==Reference==
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Structure determination of T cell protein-tyrosine phosphatase., Iversen LF, Moller KB, Pedersen AK, Peters GH, Petersen AS, Andersen HS, Branner S, Mortensen SB, Moller NP, J Biol Chem. 2002 May 31;277(22):19982-90. Epub 2002 Mar 20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11907034 11907034]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Iversen LF]]
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[[Category: Iversen, L.F.]]
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[[Category: protein tyrosine phosphatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:16:59 2008''
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Current revision

T Cell Protein-Tyrosine Phosphatase Structure

PDB ID 1l8k

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