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4ehp

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[[Image:4ehp.jpg|left|200px]]
 
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==Crystal Structure of human vinculin head domain (residues 1-252) in complex with alpha-catenin (residues 277-382)==
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The line below this paragraph, containing "STRUCTURE_4ehp", creates the "Structure Box" on the page.
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<StructureSection load='4ehp' size='340' side='right'caption='[[4ehp]], [[Resolution|resolution]] 2.66&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4ehp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EHP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.66&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
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{{STRUCTURE_4ehp| PDB=4ehp | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ehp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ehp OCA], [https://pdbe.org/4ehp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ehp RCSB], [https://www.ebi.ac.uk/pdbsum/4ehp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ehp ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/VINC_HUMAN VINC_HUMAN] Defects in VCL are the cause of cardiomyopathy dilated type 1W (CMD1W) [MIM:[https://omim.org/entry/611407 611407]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:11815424</ref> <ref>PMID:16236538</ref> Defects in VCL are the cause of familial hypertrophic cardiomyopathy type 15 (CMH15) [MIM:[https://omim.org/entry/613255 613255]. It is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.<ref>PMID:16712796</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/VINC_HUMAN VINC_HUMAN] Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.<ref>PMID:20484056</ref>
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===Crystal Structure of human vinculin head domain (residues 1-252) in complex with alpha-catenin (residues 277-382)===
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==See Also==
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*[[Catenin 3D structures|Catenin 3D structures]]
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*[[Vinculin|Vinculin]]
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==About this Structure==
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== References ==
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[[4ehp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHP OCA].
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Izard, T.]]
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[[Category: Large Structures]]
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[[Category: Rangarajan, E S.]]
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[[Category: Izard T]]
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[[Category: Adherens junction]]
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[[Category: Rangarajan ES]]
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[[Category: Cell adhesion]]
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[[Category: Helix bundle]]
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[[Category: Vinculin binding domain]]
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[[Category: Vinculin binding site]]
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Current revision

Crystal Structure of human vinculin head domain (residues 1-252) in complex with alpha-catenin (residues 277-382)

PDB ID 4ehp

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