Sandbox SouthUniversity3
From Proteopedia
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Viral DNA is highlighted here as a <scene name='Sandbox_SouthUniversity3/Human_dna_ribbon/1'>brown ribbon</scene> | Viral DNA is highlighted here as a <scene name='Sandbox_SouthUniversity3/Human_dna_ribbon/1'>brown ribbon</scene> | ||
| - | One strand of human DNA can be seen here <scene name='Sandbox_SouthUniversity3/Human-viral_dna_ribbon/3'>highlighted in green</scene> | + | One strand of human DNA can be seen here <scene name='Sandbox_SouthUniversity3/Human-viral_dna_ribbon/3'>highlighted in green</scene>. Note that one of the (brown) viral DNA strands is oriented close to and perpendicular to the human (green) strand |
| - | The drug raltegravir (Isentress)is the first drug that has made its way to market that acts as an inhibitor of HIV-integrase. It is shown <scene name='Sandbox_SouthUniversity3/ | + | The drug raltegravir (Isentress)is the first drug that has made its way to market that acts as an inhibitor of HIV-integrase. It is shown <scene name='Sandbox_SouthUniversity3/Isentress_spacefill/1'>here</scene> displayed in a space filling representation.It is easier to see the functional groups displayed as <scene name='Sandbox_SouthUniversity3/Isentress_sticks/1'>sticks</scene> |
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| + | Note the 3 oxygen atoms labeled <scene name='Sandbox_SouthUniversity3/Isentress_oxy_label/2'>here</scene>. They are a vital part of the structure, since they bind (chelate) to 2 magnesium ions within the enzyme. The oxygen atoms are highlighted here as <scene name='Sandbox_SouthUniversity3/Mg_atoms/1'>green spheres</scene> | ||
</StructureSection> | </StructureSection> | ||
Current revision
==Integrase as an anti-HIV drug target==
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