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Sandbox SouthUniversity3

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Current revision (14:42, 18 April 2012) (edit) (undo)
 
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Viral DNA is highlighted here as a <scene name='Sandbox_SouthUniversity3/Human_dna_ribbon/1'>brown ribbon</scene>
Viral DNA is highlighted here as a <scene name='Sandbox_SouthUniversity3/Human_dna_ribbon/1'>brown ribbon</scene>
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One strand of human DNA can be seen here <scene name='Sandbox_SouthUniversity3/Human-viral_dna_ribbon/3'>highlighted in green</scene>
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One strand of human DNA can be seen here <scene name='Sandbox_SouthUniversity3/Human-viral_dna_ribbon/3'>highlighted in green</scene>. Note that one of the (brown) viral DNA strands is oriented close to and perpendicular to the human (green) strand
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The drug raltegravir (Isentress)is the first drug that has made its way to market that acts as an inhibitor of HIV-integrase. It is shown <scene name='Sandbox_SouthUniversity3/Isentress_only/1'>here</scene> displayed in a space filling representation.It is easier to see the functional groups displayed as <scene name='Sandbox_SouthUniversity3/Isentress_only_sticks/1'>sticks</scene>.
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The drug raltegravir (Isentress)is the first drug that has made its way to market that acts as an inhibitor of HIV-integrase. It is shown <scene name='Sandbox_SouthUniversity3/Isentress_spacefill/1'>here</scene> displayed in a space filling representation.It is easier to see the functional groups displayed as <scene name='Sandbox_SouthUniversity3/Isentress_sticks/1'>sticks</scene>
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Note the 3 oxygen atoms labeled <scene name='Sandbox_SouthUniversity3/Isentress_oxy_label/2'>here</scene>. They are a vital part of the structure, since they bind (chelate) to 2 magnesium ions within the enzyme. The oxygen atoms are highlighted here as <scene name='Sandbox_SouthUniversity3/Mg_atoms/1'>green spheres</scene>
</StructureSection>
</StructureSection>

Current revision

==Integrase as an anti-HIV drug target==

Structure of integrase in action (PDB entry 3os1)

Drag the structure with the mouse to rotate
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