3obv

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[[Image:3obv.png|left|200px]]
 
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==Autoinhibited Formin mDia1 Structure==
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The line below this paragraph, containing "STRUCTURE_3obv", creates the "Structure Box" on the page.
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<StructureSection load='3obv' size='340' side='right'caption='[[3obv]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3obv]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OBV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OBV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FRU:FRUCTOSE'>FRU</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900003:sucrose'>PRD_900003</scene></td></tr>
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{{STRUCTURE_3obv| PDB=3obv | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3obv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3obv OCA], [https://pdbe.org/3obv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3obv RCSB], [https://www.ebi.ac.uk/pdbsum/3obv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3obv ProSAT]</span></td></tr>
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</table>
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===Autoinhibited Formin mDia1 Structure===
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== Function ==
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[https://www.uniprot.org/uniprot/DIAP1_MOUSE DIAP1_MOUSE] Acts in a Rho-dependent manner to recruit PFY1 to the membrane. Required for the assembly of F-actin structures, such as actin cables and stress fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. Required for cytokinesis, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration. Has neurite outgrowth promoting activity. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity).<ref>PMID:9214622</ref> <ref>PMID:10678165</ref> <ref>PMID:15044801</ref> <ref>PMID:18572016</ref>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_20927343}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 20927343 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_20927343}}
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==About this Structure==
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[[3obv]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OBV OCA].
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==Reference==
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<ref group="xtra">PMID:020927343</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Otomo, T.]]
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[[Category: Otomo T]]
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[[Category: Rosen, M K.]]
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[[Category: Rosen MK]]
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[[Category: Tomchick, D R.]]
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[[Category: Tomchick DR]]
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[[Category: Actin]]
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[[Category: Autoinhibition]]
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[[Category: Cytoskeleton]]
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[[Category: Nucleation]]
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[[Category: Structural protein]]
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Current revision

Autoinhibited Formin mDia1 Structure

PDB ID 3obv

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