2lmb

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[[Image:2lmb.png|left|200px]]
 
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==Solution Structure of C-terminal RAGE (ctRAGE)==
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The line below this paragraph, containing "STRUCTURE_2lmb", creates the "Structure Box" on the page.
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<StructureSection load='2lmb' size='340' side='right'caption='[[2lmb]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2lmb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LMB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LMB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lmb OCA], [https://pdbe.org/2lmb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lmb RCSB], [https://www.ebi.ac.uk/pdbsum/2lmb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lmb ProSAT]</span></td></tr>
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{{STRUCTURE_2lmb| PDB=2lmb | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RAGE_HUMAN RAGE_HUMAN] Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space.<ref>PMID:19906677</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The receptor for advanced glycation end products (RAGE) is a multiligand cell surface macromolecule that plays a central role in the etiology of diabetes complications, inflammation, and neurodegeneration. The cytoplasmic domain of RAGE (C-terminal RAGE; ctRAGE) is critical for RAGE-dependent signal transduction. As the most membrane-proximal event, mDia1 binds to ctRAGE, and it is essential for RAGE ligand-stimulated phosphorylation of AKT and cell proliferation/migration. We show that ctRAGE contains an unusual alpha-turn that mediates the mDia1-ctRAGE interaction and is required for RAGE-dependent signaling. The results establish a novel mechanism through which an extracellular signal initiated by RAGE ligands regulates RAGE signaling in a manner requiring mDia1.
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===Solution Structure of C-terminal RAGE (ctRAGE)===
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Signal transduction in receptor for advanced glycation end products (RAGE): solution structure of C-terminal rage (ctRAGE) and its binding to mDia1.,Rai V, Maldonado AY, Burz DS, Reverdatto S, Schmidt AM, Shekhtman A J Biol Chem. 2012 Feb 10;287(7):5133-44. Epub 2011 Dec 21. PMID:22194616<ref>PMID:22194616</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2lmb" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 22194616 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22194616}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2lmb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LMB OCA].
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==Reference==
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<ref group="xtra">PMID:022194616</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Burz, D S.]]
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[[Category: Large Structures]]
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[[Category: Maldonado, A Y.]]
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[[Category: Burz DS]]
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[[Category: Rai, V.]]
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[[Category: Maldonado AY]]
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[[Category: Reverdatto, S.]]
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[[Category: Rai V]]
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[[Category: Schmidt, A.]]
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[[Category: Reverdatto S]]
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[[Category: Shekhtman, A.]]
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[[Category: Schmidt A]]
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[[Category: Cytosolic tail]]
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[[Category: Shekhtman A]]
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[[Category: Signal transduction receptor]]
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[[Category: Signaling protein]]
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Current revision

Solution Structure of C-terminal RAGE (ctRAGE)

PDB ID 2lmb

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