3rn4

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[[Image:3rn4.png|left|200px]]
 
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==Crystal structure of iron-substituted Sod2 from Saccharomyces cerevisiae==
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The line below this paragraph, containing "STRUCTURE_3rn4", creates the "Structure Box" on the page.
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<StructureSection load='3rn4' size='340' side='right'caption='[[3rn4]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3rn4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RN4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RN4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
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{{STRUCTURE_3rn4| PDB=3rn4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rn4 OCA], [https://pdbe.org/3rn4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rn4 RCSB], [https://www.ebi.ac.uk/pdbsum/3rn4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rn4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SODM_YEAST SODM_YEAST] Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The manganese-specific superoxide dismutase SOD2 from the yeast Saccharomyces cerevisiae is a protein that resides in the mitochondrion and protects it against attack by superoxide radicals. However, a high iron concentration in the mitochondria results in iron misincorporation at the active site, with subsequent inactivation of SOD2. Here, the crystal structures of SOD2 bound with the native metal manganese and with the `wrong' metal iron are presented at 2.05 and 1.79 A resolution, respectively. Structural comparison of the two structures shows no significant conformational alteration in the overall structure or in the active site upon binding the non-native metal iron. Moreover, residues Asp163 and Lys80 are proposed to potentially be responsible for the metal specificity of the Mn-specific SOD. Additionally, the surface-potential distribution of SOD2 revealed a conserved positively charged electrostatic zone in the proximity of the active site that probably functions in the same way as in Cu/Zn-SODs by facilitating the diffusion of the superoxide anion to the metal ion.
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===Crystal structure of iron-substituted Sod2 from Saccharomyces cerevisiae===
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Structures of native and Fe-substituted SOD2 from Saccharomyces cerevisiae.,Kang Y, He YX, Zhao MX, Li WF Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt 10):1173-8., Epub 2011 Sep 24. PMID:22102021<ref>PMID:22102021</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3rn4" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_22102021}}, adds the Publication Abstract to the page
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*[[Superoxide dismutase 3D structures|Superoxide dismutase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22102021 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22102021}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3rn4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RN4 OCA].
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Cheng W]]
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==Reference==
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[[Category: He Y-X]]
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<ref group="xtra">PMID:022102021</ref><references group="xtra"/>
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[[Category: Kang Y]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Li W-F]]
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[[Category: Superoxide dismutase]]
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[[Category: Zhou C-Z]]
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[[Category: Cheng, W.]]
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[[Category: He, Y X.]]
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[[Category: Kang, Y.]]
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[[Category: Li, W F.]]
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[[Category: Zhou, C Z.]]
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[[Category: Iron-binding]]
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[[Category: Mitochondrial manganese superoxide dismutase]]
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[[Category: Mitochondrion]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal structure of iron-substituted Sod2 from Saccharomyces cerevisiae

PDB ID 3rn4

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