3uom
From Proteopedia
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- | [[Image:3uom.png|left|200px]] | ||
- | + | ==Ca2+ complex of Human skeletal calsequestrin== | |
- | + | <StructureSection load='3uom' size='340' side='right'caption='[[3uom]], [[Resolution|resolution]] 2.02Å' scene=''> | |
- | + | == Structural highlights == | |
- | + | <table><tr><td colspan='2'>[[3uom]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UOM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UOM FirstGlance]. <br> | |
- | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.02Å</td></tr> | |
- | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr> | |
- | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uom OCA], [https://pdbe.org/3uom PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uom RCSB], [https://www.ebi.ac.uk/pdbsum/3uom PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uom ProSAT]</span></td></tr> | |
- | + | </table> | |
- | + | == Function == | |
- | + | [https://www.uniprot.org/uniprot/CASQ1_HUMAN CASQ1_HUMAN] Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction.<ref>PMID:22337878</ref> <ref>PMID:22337878</ref> | |
- | + | == References == | |
- | < | + | <references/> |
- | + | __TOC__ | |
- | + | </StructureSection> | |
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- | [[3uom]] is a 6 chain structure with sequence from [ | + | |
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
- | [[Category: | + | [[Category: Large Structures]] |
- | [[Category: | + | [[Category: Danna BR]] |
- | [[Category: | + | [[Category: Kang CH]] |
- | [[Category: | + | [[Category: Lewis KM]] |
- | [[Category: | + | [[Category: Nissen MS]] |
- | [[Category: | + | [[Category: Sanchez EJ]] |
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Current revision
Ca2+ complex of Human skeletal calsequestrin
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Categories: Homo sapiens | Large Structures | Danna BR | Kang CH | Lewis KM | Nissen MS | Sanchez EJ