3vg0

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[[Image:3vg0.png|left|200px]]
 
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==Antibody Fab fragment==
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The line below this paragraph, containing "STRUCTURE_3vg0", creates the "Structure Box" on the page.
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<StructureSection load='3vg0' size='340' side='right'caption='[[3vg0]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3vg0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VG0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VG0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.27&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3vg0| PDB=3vg0 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vg0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vg0 OCA], [https://pdbe.org/3vg0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vg0 RCSB], [https://www.ebi.ac.uk/pdbsum/3vg0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vg0 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Leptin regulates energy homeostasis, fertility, and the immune system, making it an important drug target. However, due to a complete lack of structural data for the obesity receptor (ObR), leptin's mechanism of receptor activation remains poorly understood. We have crystallized the Fab fragment of a leptin-blocking monoclonal antibody (9F8), both in its uncomplexed state and bound to the leptin-binding domain (LBD) of human ObR. We describe the structure of the LBD-9F8 Fab complex and the conformational changes in 9F8 associated with LBD binding. A molecular model of the putative leptin-LBD complex reveals that 9F8 Fab blocks leptin binding through only a small (10%) overlap in their binding sites, and that leptin binding is likely to involve an induced fit mechanism. This crystal structure of the leptin-binding domain of the obesity receptor will facilitate the design of therapeutics to modulate leptin signaling.
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===Antibody Fab fragment===
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Structure of the human obesity receptor leptin-binding domain reveals the mechanism of leptin antagonism by a monoclonal antibody.,Carpenter B, Hemsworth GR, Wu Z, Maamra M, Strasburger CJ, Ross RJ, Artymiuk PJ Structure. 2012 Mar 7;20(3):487-97. PMID:22405007<ref>PMID:22405007</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3vg0" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_22405007}}, adds the Publication Abstract to the page
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*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22405007 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22405007}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3vg0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VG0 OCA].
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==Reference==
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<ref group="xtra">PMID:022405007</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Artymiuk, P J.]]
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[[Category: Artymiuk PJ]]
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[[Category: Carpenter, B.]]
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[[Category: Carpenter B]]
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[[Category: Hemsworth, G R.]]
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[[Category: Hemsworth GR]]
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[[Category: Ross, R J.]]
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[[Category: Ross RJ]]
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[[Category: Antibody fab fragment]]
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[[Category: Fab fragment]]
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[[Category: Immune system]]
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[[Category: Immunoglobulin fold]]
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[[Category: Lbd domain of obr receptor]]
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[[Category: N-linked glycosylation site]]
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Current revision

Antibody Fab fragment

PDB ID 3vg0

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