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2zvr

From Proteopedia

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[[Image:2zvr.png|left|200px]]
 
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==Crystal structure of a D-tagatose 3-epimerase-related protein from Thermotoga maritima==
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The line below this paragraph, containing "STRUCTURE_2zvr", creates the "Structure Box" on the page.
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<StructureSection load='2zvr' size='340' side='right'caption='[[2zvr]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2zvr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZVR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zvr OCA], [https://pdbe.org/2zvr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zvr RCSB], [https://www.ebi.ac.uk/pdbsum/2zvr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zvr ProSAT]</span></td></tr>
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{{STRUCTURE_2zvr| PDB=2zvr | SCENE= }}
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</table>
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== Function ==
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===Crystal structure of a D-tagatose 3-epimerase-related protein from Thermotoga maritima===
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[https://www.uniprot.org/uniprot/IOLO_THEMA IOLO_THEMA] Catalyzes the reversible epimerization between 5-keto-L-gluconate (5-dehydro-L-gluconate) and D-tagaturonate, and thus probably functions in a myo-inositol degradation pathway together with IolG, IolM and IolN (PubMed:23441918). Is not active on the enantiomer 5-keto-D-gluconate (PubMed:23441918). Was also shown to be a nonphosphorylated sugar isomerase with broad substrate specificity in vitro (PubMed:28258150). Is able to catalyze the reversible C3-epimerization of L-ribulose to L-xylulose, D-ribulose to D-xylulose, D-psicose to D-fructose, and D-tagatose to D-sorbose, with a substrate preference for ketopentoses rather than ketohexoses (PubMed:28258150). Also catalyzes the aldose-ketose isomerization reaction from either D-erythrose or D-threose to D-erythrulose (PubMed:28258150). Exhibits no activity for C4-epimerization of D-tagatose to D-fructose (PubMed:28258150).<ref>PMID:23441918</ref> <ref>PMID:28258150</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_19255464}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 19255464 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zv/2zvr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_19255464}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zvr ConSurf].
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[[2zvr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVR OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019255464</ref><references group="xtra"/>
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__TOC__
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[[Category: Thermotoga maritima]]
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</StructureSection>
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[[Category: Ohshima, T.]]
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[[Category: Large Structures]]
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[[Category: Sakuraba, H.]]
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[[Category: D-tagatose 3-epimerase]]
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[[Category: Hyperthermophile]]
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[[Category: Isomerase]]
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[[Category: Ketohexose 3-epimerase]]
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[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
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[[Category: Ohshima T]]
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[[Category: Sakuraba H]]

Current revision

Crystal structure of a D-tagatose 3-epimerase-related protein from Thermotoga maritima

PDB ID 2zvr

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