4ec2
From Proteopedia
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- | '''Unreleased structure''' | ||
- | + | ==Crystal structure of trimeric frataxin from the yeast Saccharomyces cerevisiae, complexed with ferrous== | |
+ | <StructureSection load='4ec2' size='340' side='right'caption='[[4ec2]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
+ | == Structural highlights == | ||
+ | <table><tr><td colspan='2'>[[4ec2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EC2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EC2 FirstGlance]. <br> | ||
+ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.002Å</td></tr> | ||
+ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr> | ||
+ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ec2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ec2 OCA], [https://pdbe.org/4ec2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ec2 RCSB], [https://www.ebi.ac.uk/pdbsum/4ec2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ec2 ProSAT]</span></td></tr> | ||
+ | </table> | ||
+ | == Function == | ||
+ | [https://www.uniprot.org/uniprot/FRDA_YEAST FRDA_YEAST] Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. Plays a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). Can store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. May be involved in regulation of the mitochondrial electron transport chain.<ref>PMID:9180083</ref> <ref>PMID:9988680</ref> <ref>PMID:15961414</ref> <ref>PMID:16371422</ref> <ref>PMID:19884169</ref> <ref>PMID:17027502</ref> | ||
- | + | ==See Also== | |
- | + | *[[Frataxin 3D Structures|Frataxin 3D Structures]] | |
- | + | == References == | |
+ | <references/> | ||
+ | __TOC__ | ||
+ | </StructureSection> | ||
+ | [[Category: Large Structures]] | ||
+ | [[Category: Saccharomyces cerevisiae S288C]] | ||
+ | [[Category: Al-Karadaghi S]] | ||
+ | [[Category: Gakh O]] | ||
+ | [[Category: Isaya G]] | ||
+ | [[Category: Rajan S]] | ||
+ | [[Category: Soderberg CAG]] |
Current revision
Crystal structure of trimeric frataxin from the yeast Saccharomyces cerevisiae, complexed with ferrous
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