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4enk
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4enk is ON HOLD Authors: Tubbs, JL, Arvai, AS, Tainer, JA Description: Crystal structure of S. pombe Atl1 in complex with damaged DNA containing O6...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of S. pombe Atl1 in complex with damaged DNA containing O6-propylguanine== | |
| - | + | <StructureSection load='4enk' size='340' side='right'caption='[[4enk]], [[Resolution|resolution]] 3.04Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4enk]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ENK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ENK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.0445Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6PO:9-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-6-PROPOXY-9H-PURIN-2-AMINE'>6PO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4enk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4enk OCA], [https://pdbe.org/4enk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4enk RCSB], [https://www.ebi.ac.uk/pdbsum/4enk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4enk ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ATL1_SCHPO ATL1_SCHPO] Acts as a DNA damage recognition factor. Required for DNA repair from mutagenic O(6)-alkylguanine adducts. Binds O(6)-alkylguanine lesions providing a signal for other DNA repair pathways. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Schizosaccharomyces pombe 972h-]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Arvai AS]] | ||
| + | [[Category: Tainer JA]] | ||
| + | [[Category: Tubbs JL]] | ||
Current revision
Crystal structure of S. pombe Atl1 in complex with damaged DNA containing O6-propylguanine
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