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4epi
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The crystal structure of pesticin-T4 lysozyme hybrid stabilized by engineered disulfide bonds== |
| + | <StructureSection load='4epi' size='340' side='right'caption='[[4epi]], [[Resolution|resolution]] 1.74Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4epi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EPI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EPI FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4epi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4epi OCA], [https://pdbe.org/4epi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4epi RCSB], [https://www.ebi.ac.uk/pdbsum/4epi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4epi ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref> [https://www.uniprot.org/uniprot/Q57159_YERPE Q57159_YERPE] | ||
| - | + | ==See Also== | |
| - | + | *[[Lysozyme 3D structures|Lysozyme 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia virus T4]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Yersinia pestis]] | ||
| + | [[Category: Barnard T]] | ||
| + | [[Category: Buchanan SK]] | ||
| + | [[Category: Fairman JW]] | ||
| + | [[Category: Lukacik P]] | ||
| + | [[Category: Noinaj N]] | ||
| + | [[Category: Seddiki N]] | ||
Current revision
The crystal structure of pesticin-T4 lysozyme hybrid stabilized by engineered disulfide bonds
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