4er3
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4er3 is ON HOLD Authors: Wernimont, A.K., Tempel, W., Yu, W., Scopton, A., Li, Y., Nguyen, K.T., Federation, A., Marineau, J., Qi, J., Vedadi, M., B...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Human DOT1L in complex with inhibitor EPZ004777== | |
| + | <StructureSection load='4er3' size='340' side='right'caption='[[4er3]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4er3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ER3 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0QK:7-{5-[(3-{[(4-TERT-BUTYLPHENYL)CARBAMOYL]AMINO}PROPYL)(PROPAN-2-YL)AMINO]-5-DEOXY-BETA-D-RIBOFURANOSYL}-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE'>0QK</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4er3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4er3 OCA], [https://pdbe.org/4er3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4er3 RCSB], [https://www.ebi.ac.uk/pdbsum/4er3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4er3 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA. | ||
| - | + | ==See Also== | |
| - | + | *[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Bountra C]] | ||
| + | [[Category: Bradner JE]] | ||
| + | [[Category: Brown PJ]] | ||
| + | [[Category: Edwards AM]] | ||
| + | [[Category: Federation A]] | ||
| + | [[Category: Li Y]] | ||
| + | [[Category: Marineau J]] | ||
| + | [[Category: Nguyen KT]] | ||
| + | [[Category: Qi J]] | ||
| + | [[Category: Schapira M]] | ||
| + | [[Category: Scopton A]] | ||
| + | [[Category: Tempel W]] | ||
| + | [[Category: Vedadi M]] | ||
| + | [[Category: Wernimont AK]] | ||
| + | [[Category: Yu W]] | ||
Current revision
Crystal Structure of Human DOT1L in complex with inhibitor EPZ004777
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Bradner JE | Brown PJ | Edwards AM | Federation A | Li Y | Marineau J | Nguyen KT | Qi J | Schapira M | Scopton A | Tempel W | Vedadi M | Wernimont AK | Yu W
