4er6
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4er6 is ON HOLD Authors: Wernimont, A.K., Tempel, W., Yu, W., Scopton, A., Li, Y., Nguyen, K.T., Vedadi, M., Bradner, J.E., Schapira, M., Arrowsmith...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human DOT1L in complex with inhibitor SGC0946== | |
| + | <StructureSection load='4er6' size='340' side='right'caption='[[4er6]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4er6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ER6 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AW2:5-BROMO-7-{5-[(3-{[(4-TERT-BUTYLPHENYL)CARBAMOYL]AMINO}PROPYL)(PROPAN-2-YL)AMINO]-5-DEOXY-BETA-D-RIBOFURANOSYL}-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE'>AW2</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4er6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4er6 OCA], [https://pdbe.org/4er6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4er6 RCSB], [https://www.ebi.ac.uk/pdbsum/4er6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4er6 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA. | ||
| - | + | ==See Also== | |
| - | + | *[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Bountra C]] | ||
| + | [[Category: Bradner JE]] | ||
| + | [[Category: Brown PJ]] | ||
| + | [[Category: Edwards AM]] | ||
| + | [[Category: Li Y]] | ||
| + | [[Category: Nguyen KT]] | ||
| + | [[Category: Schapira M]] | ||
| + | [[Category: Scopton A]] | ||
| + | [[Category: Tempel W]] | ||
| + | [[Category: Vedadi M]] | ||
| + | [[Category: Wernimont AK]] | ||
| + | [[Category: Yu W]] | ||
Current revision
Crystal structure of human DOT1L in complex with inhibitor SGC0946
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Bradner JE | Brown PJ | Edwards AM | Li Y | Nguyen KT | Schapira M | Scopton A | Tempel W | Vedadi M | Wernimont AK | Yu W
