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3rr4
From Proteopedia
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| - | [[Image:3rr4.jpg|left|200px]] | ||
| - | + | ==tRNA-Guanine Transglycosylase in complex with N-Methyl-lin-Benzoguanine Inhibitor== | |
| - | + | <StructureSection load='3rr4' size='340' side='right'caption='[[3rr4]], [[Resolution|resolution]] 1.68Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3rr4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zymomonas_mobilis Zymomonas mobilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RR4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RR4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68Å</td></tr> | |
| - | --> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HRD:2,6-BIS(METHYLAMINO)-1,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE'>HRD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rr4 OCA], [https://pdbe.org/3rr4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rr4 RCSB], [https://www.ebi.ac.uk/pdbsum/3rr4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rr4 ProSAT]</span></td></tr> | |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168] | ||
| - | === | + | ==See Also== |
| - | + | *[[TRNA-guanine transglycosylase 3D structures|TRNA-guanine transglycosylase 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | [[ | + | [[Category: Large Structures]] |
[[Category: Zymomonas mobilis]] | [[Category: Zymomonas mobilis]] | ||
| - | + | [[Category: Heine A]] | |
| - | [[Category: Heine | + | [[Category: Immekus F]] |
| - | [[Category: Immekus | + | [[Category: Klebe G]] |
| - | [[Category: Klebe | + | |
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Current revision
tRNA-Guanine Transglycosylase in complex with N-Methyl-lin-Benzoguanine Inhibitor
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