4dk9

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[[Image:4dk9.jpg|left|200px]]
 
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==Crystal Structure of MBD4 Catalytic Domain Bound to Abasic DNA==
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The line below this paragraph, containing "STRUCTURE_4dk9", creates the "Structure Box" on the page.
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<StructureSection load='4dk9' size='340' side='right'caption='[[4dk9]], [[Resolution|resolution]] 2.76&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4dk9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DK9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DK9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.76&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3DR:1,2-DIDEOXYRIBOFURANOSE-5-PHOSPHATE'>3DR</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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{{STRUCTURE_4dk9| PDB=4dk9 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dk9 OCA], [https://pdbe.org/4dk9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dk9 RCSB], [https://www.ebi.ac.uk/pdbsum/4dk9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dk9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MBD4_HUMAN MBD4_HUMAN] Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.<ref>PMID:10097147</ref> <ref>PMID:10930409</ref>
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===Crystal Structure of MBD4 Catalytic Domain Bound to Abasic DNA===
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==See Also==
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*[[Methyl CpG binding protein 3D structures|Methyl CpG binding protein 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[4dk9]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DK9 OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Drohat, A C.]]
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[[Category: Large Structures]]
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[[Category: Manvilla, B A.]]
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[[Category: Drohat AC]]
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[[Category: Toth, E A.]]
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[[Category: Manvilla BA]]
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[[Category: Hydrolase-dna complex]]
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[[Category: Toth EA]]
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[[Category: Protein-dna complex]]
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Current revision

Crystal Structure of MBD4 Catalytic Domain Bound to Abasic DNA

PDB ID 4dk9

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