2exe

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:40, 23 August 2023) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2exe.png|left|200px]]
 
-
<!--
+
==Crystal structure of the phosphorylated CLK3==
-
The line below this paragraph, containing "STRUCTURE_2exe", creates the "Structure Box" on the page.
+
<StructureSection load='2exe' size='340' side='right'caption='[[2exe]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2exe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EXE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EXE FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2exe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2exe OCA], [https://pdbe.org/2exe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2exe RCSB], [https://www.ebi.ac.uk/pdbsum/2exe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2exe ProSAT]</span></td></tr>
-
{{STRUCTURE_2exe| PDB=2exe | SCENE= }}
+
</table>
-
 
+
== Function ==
-
===Crystal structure of the phosphorylated CLK3===
+
[https://www.uniprot.org/uniprot/CLK3_HUMAN CLK3_HUMAN] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.<ref>PMID:9637771</ref> <ref>PMID:19168442</ref>
-
 
+
== Evolutionary Conservation ==
-
 
+
[[Image:Consurf_key_small.gif|200px|right]]
-
==About this Structure==
+
Check<jmol>
-
[[2exe]] is a 1 chain structure of [[Dual specificity protein kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EXE OCA].
+
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/2exe_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2exe ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Dual specificity protein kinase|Dual specificity protein kinase]]
+
*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Receptor protein-tyrosine kinase]]
+
[[Category: Large Structures]]
-
[[Category: Arrowsmith, C.]]
+
[[Category: Arrowsmith C]]
-
[[Category: Ball, L J.]]
+
[[Category: Ball LJ]]
-
[[Category: Bullock, A.]]
+
[[Category: Bullock A]]
-
[[Category: Das, S.]]
+
[[Category: Das S]]
-
[[Category: Delft, F von.]]
+
[[Category: Edwards A]]
-
[[Category: Edwards, A.]]
+
[[Category: Fedorov O]]
-
[[Category: Fedorov, O.]]
+
[[Category: Johansson C]]
-
[[Category: Johansson, C.]]
+
[[Category: Knapp S]]
-
[[Category: Knapp, S.]]
+
[[Category: Papagrigoriou E]]
-
[[Category: Papagrigoriou, E.]]
+
[[Category: Rellos P]]
-
[[Category: Rellos, P.]]
+
[[Category: Savitsky P]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Sobott F]]
-
[[Category: Savitsky, P.]]
+
[[Category: Sundstrom M]]
-
[[Category: Sobott, F.]]
+
[[Category: Turnbull A]]
-
[[Category: Sundstrom, M.]]
+
[[Category: Ugochukwu E]]
-
[[Category: Turnbull, A.]]
+
[[Category: Weigelt J]]
-
[[Category: Ugochukwu, E.]]
+
[[Category: Von Delft F]]
-
[[Category: Weigelt, J.]]
+
-
[[Category: Dual-specificity kinase]]
+
-
[[Category: Sgc]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Structural genomics consortium]]
+
-
[[Category: Transferase]]
+

Current revision

Crystal structure of the phosphorylated CLK3

PDB ID 2exe

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2exe"
Personal tools