2fci

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[[Image:2fci.png|left|200px]]
 
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==Structural basis for the requirement of two phosphotyrosines in signaling mediated by Syk tyrosine kinase==
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The line below this paragraph, containing "STRUCTURE_2fci", creates the "Structure Box" on the page.
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<StructureSection load='2fci' size='340' side='right'caption='[[2fci]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2fci]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FCI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=GMA:4-AMIDO-4-CARBAMOYL-BUTYRIC+ACID'>GMA</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
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{{STRUCTURE_2fci| PDB=2fci | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fci OCA], [https://pdbe.org/2fci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fci RCSB], [https://www.ebi.ac.uk/pdbsum/2fci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fci ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q32PK0_BOVIN Q32PK0_BOVIN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fc/2fci_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fci ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The protein-tyrosine kinase Syk couples immune recognition receptors to multiple signal transduction pathways, including the mobilization of calcium and the activation of NFAT. The ability of Syk to regulate signaling is influenced by its phosphorylation on tyrosine residues within the linker B region. The phosphorylation of both Y342 and Y346 is necessary for optimal signaling from the B cell receptor for antigen. The SH2 domains of multiple signaling proteins share the ability to bind this doubly phosphorylated site. The NMR structure of the C-terminal SH2 domain of PLCgamma (PLCC) bound to a doubly phosphorylated Syk peptide reveals a novel mode of phosphotyrosine recognition. PLCC undergoes extensive conformational changes upon binding to form a second phosphotyrosine-binding pocket in which pY346 is largely desolvated and stabilized through electrostatic interactions. The formation of the second binding pocket is distinct from other modes of phosphotyrosine recognition in SH2-protein association. The dependence of signaling on simultaneous phosphorylation of these two tyrosine residues offers a new mechanism to fine-tune the cellular response to external stimulation.
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===Structural basis for the requirement of two phosphotyrosines in signaling mediated by Syk tyrosine kinase===
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Structural basis for the requirement of two phosphotyrosine residues in signaling mediated by Syk tyrosine kinase.,Groesch TD, Zhou F, Mattila S, Geahlen RL, Post CB J Mol Biol. 2006 Mar 10;356(5):1222-36. Epub 2005 Dec 27. PMID:16410013<ref>PMID:16410013</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16410013}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2fci" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16410013 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16410013}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2fci]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCI OCA].
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==Reference==
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<ref group="xtra">PMID:016410013</ref><references group="xtra"/>
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Phosphoinositide phospholipase C]]
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[[Category: Large Structures]]
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[[Category: Geahlen, R L.]]
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[[Category: Geahlen RL]]
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[[Category: Groesch, T D.]]
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[[Category: Groesch TD]]
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[[Category: Mattila, S.]]
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[[Category: Mattila S]]
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[[Category: Post, C B.]]
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[[Category: Post CB]]
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[[Category: Zhou, F.]]
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[[Category: Zhou F]]
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[[Category: Hydrolase]]
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[[Category: Phosphopeptide]]
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[[Category: Plcc]]
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[[Category: Plcgamma]]
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[[Category: Sh2 domain]]
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[[Category: Syk kinase]]
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Current revision

Structural basis for the requirement of two phosphotyrosines in signaling mediated by Syk tyrosine kinase

PDB ID 2fci

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