3uvt

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[[Image:3uvt.png|left|200px]]
 
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==Crystal structure of the third catalytic domain of ERp46==
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The line below this paragraph, containing "STRUCTURE_3uvt", creates the "Structure Box" on the page.
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<StructureSection load='3uvt' size='340' side='right'caption='[[3uvt]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3uvt]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UVT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UVT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3uvt| PDB=3uvt | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uvt OCA], [https://pdbe.org/3uvt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uvt RCSB], [https://www.ebi.ac.uk/pdbsum/3uvt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uvt ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TXND5_HUMAN TXND5_HUMAN] Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Protein disulfide isomerases are responsible for catalyzing the proper oxidation and isomerization of disulfide bonds of newly synthesized proteins in the endoplasmic reticulum. Here, the crystal structure of the third catalytic domain of protein disulfide isomerase ERp46 (also known as protein disulfide isomerase A5 and TXNDC5) was determined to 2.0 A resolution. The structure shows a typical thioredoxin-like fold, but also identifies regions of high structural variability. In particular, the loop between helix alpha2 and strand beta3 adopts strikingly different conformations among the five chains of the asymmetric unit. Cys381 and Cys388 form a structural disulfide and its absence in one of the molecules leads to dramatic conformational changes. The tryptophan residue Trp349 of this molecule inserts into the cavity formed by helices alpha1 and alpha3 of a neighbouring molecule, potentially mimicking the interactions of ERp46 with misfolded substrates.
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===Crystal structure of the third catalytic domain of ERp46===
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Structure of the third catalytic domain of the protein disulfide isomerase ERp46.,Gulerez IE, Kozlov G, Rosenauer A, Gehring K Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Apr 1;68(Pt 4):378-81., Epub 2012 Mar 27. PMID:22505402<ref>PMID:22505402</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3uvt" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_22505402}}, adds the Publication Abstract to the page
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*[[ER-resident protein|ER-resident protein]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22505402 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22505402}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[3uvt]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UVT OCA].
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==Reference==
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<ref group="xtra">PMID:022505402</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein disulfide-isomerase]]
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[[Category: Large Structures]]
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[[Category: Gehring, K.]]
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[[Category: Gehring K]]
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[[Category: Gulerez, I E.]]
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[[Category: Gulerez IE]]
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[[Category: Kozlov, G.]]
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[[Category: Kozlov G]]
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[[Category: Isomerase]]
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[[Category: Thioredoxin-like fold]]
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Current revision

Crystal structure of the third catalytic domain of ERp46

PDB ID 3uvt

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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