4e1r

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'''Unreleased structure'''
 
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The entry 4e1r is ON HOLD until Paper Publication
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==Crystal structure of the dimerization domain of Lsr2 from Mycobacterium tuberculosis in the P 31 2 1 space group==
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<StructureSection load='4e1r' size='340' side='right'caption='[[4e1r]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
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Authors: Summers, E.L., Meindl, K., Uson, I., Arcus, V.L.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4e1r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E1R FirstGlance]. <br>
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Description: Crystal structure of the dimerization domain of Lsr2 from Mycobacterium tuberculosis in the P 31 2 1 space group
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.041&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e1r OCA], [https://pdbe.org/4e1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e1r RCSB], [https://www.ebi.ac.uk/pdbsum/4e1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e1r ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LSR2_MYCTU LSR2_MYCTU] DNA-bridging protein that has both architectural and regulatory roles. Influences the organization of chromatin and gene expression by binding non-specifically to DNA, with a preference for AT-rich sequences, and bridging distant DNA segments. Represses expression of multiple genes involved in a broad range of cellular processes, including major virulence factors or antibiotic-induced genes, such as iniBAC or efpA. May coordinate global gene regulation and virulence. Also protects mycobacteria against reactive oxygen intermediates during macrophage infection by acting as a physical barrier to DNA degradation.<ref>PMID:17590082</ref> <ref>PMID:18187505</ref> <ref>PMID:19237572</ref> <ref>PMID:20133735</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Arcus VL]]
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[[Category: Meindl K]]
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[[Category: Summers EL]]
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[[Category: Uson I]]

Current revision

Crystal structure of the dimerization domain of Lsr2 from Mycobacterium tuberculosis in the P 31 2 1 space group

PDB ID 4e1r

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