4esw
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4esw is ON HOLD Authors: Fenwick, M.K., Huang, S., Zhang, Y., Lai, R., Hazra, A., Rajashankar, K, Philmus, B., Kinsland, C., Sanders, J., Begley, T....) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of C. albicans Thi5 H66G mutant== | |
| - | + | <StructureSection load='4esw' size='340' side='right'caption='[[4esw]], [[Resolution|resolution]] 1.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4esw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans_WO-1 Candida albicans WO-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ESW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ESW FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4esw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4esw OCA], [https://pdbe.org/4esw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4esw RCSB], [https://www.ebi.ac.uk/pdbsum/4esw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4esw ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/THI5_CANAW THI5_CANAW] Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.<ref>PMID:22568620</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Candida albicans WO-1]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Begley TP]] | ||
| + | [[Category: Ealick SE]] | ||
| + | [[Category: Fenwick MK]] | ||
| + | [[Category: Hazra A]] | ||
| + | [[Category: Huang S]] | ||
| + | [[Category: Kinsland C]] | ||
| + | [[Category: Lai R]] | ||
| + | [[Category: Philmus B]] | ||
| + | [[Category: Rajashankar K]] | ||
| + | [[Category: Sanders J]] | ||
| + | [[Category: Zhang Y]] | ||
Current revision
Crystal structure of C. albicans Thi5 H66G mutant
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Categories: Candida albicans WO-1 | Large Structures | Begley TP | Ealick SE | Fenwick MK | Hazra A | Huang S | Kinsland C | Lai R | Philmus B | Rajashankar K | Sanders J | Zhang Y
