2lha

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[[Image:2lha.jpg|left|200px]]
 
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==Solution structure of C2B with IP6==
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The line below this paragraph, containing "STRUCTURE_2lha", creates the "Structure Box" on the page.
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<StructureSection load='2lha' size='340' side='right'caption='[[2lha]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2lha]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LHA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LHA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene></td></tr>
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{{STRUCTURE_2lha| PDB=2lha | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lha OCA], [https://pdbe.org/2lha PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lha RCSB], [https://www.ebi.ac.uk/pdbsum/2lha PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lha ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SYT1_HUMAN SYT1_HUMAN] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Synaptotagmin I is a synaptic vesicle membrane protein that serves as a multifunctional regulator during the exocytosis of neurotransmitter release. It contains C2A and C2B domains. The binding of Ca(2+) to the C2A domain activates the exocytosis of secretory vesicles, while the binding of inositol polyphosphates (IP4-IP6) to the C2B domain inhibits this process. To understand the IP6-induced inhibition of exocytosis of secretory vesicles, we determined the three-dimensional structure of the C2B-IP6 complex by nuclear magnetic resonance (NMR). In this study, we have determined the binding constant by isothermal titration calorimetry. The circular dichroism measurements demonstrated that IP6 can stabilize the C2B molecule. We identified the binding site using (1)H-(15)N heteronuclear single-quantum coherence spectroscopy titration data and determined the structure of the C2B-IP6 complex using multidimensional NMR studies. This information will aid in the design of better pharmacological treatments for neurological disorders.
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===Solution structure of C2B with IP6===
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Molecular Level Interaction of Inositol Hexaphosphate with the C2B Domain of Human Synaptotagmin I.,Joung MJ, Mohan SK, Yu C Biochemistry. 2012 May 1;51(17):3675-83. Epub 2012 Apr 18. PMID:22475172<ref>PMID:22475172</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2lha" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_22475172}}, adds the Publication Abstract to the page
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*[[Synaptotagmin 3D structures|Synaptotagmin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22475172 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22475172}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2lha]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LHA OCA].
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==Reference==
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<ref group="xtra">PMID:022475172</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Joung, M.]]
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[[Category: Large Structures]]
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[[Category: Mohan, S K.]]
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[[Category: Joung M]]
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[[Category: Yu, C.]]
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[[Category: Mohan SK]]
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[[Category: Beta-sheet protein]]
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[[Category: Yu C]]
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[[Category: Calcium binding protein]]
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[[Category: Metal binding protein]]
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[[Category: Protein-drug complex]]
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Current revision

Solution structure of C2B with IP6

PDB ID 2lha

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