3r94

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[[Image:3r94.jpg|left|200px]]
 
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==AKR1C3 complex with flurbiprofen==
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The line below this paragraph, containing "STRUCTURE_3r94", creates the "Structure Box" on the page.
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<StructureSection load='3r94' size='340' side='right'caption='[[3r94]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3r94]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R94 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R94 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.013&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FLR:(2R)-2-(3-FLUORO-4-PHENYL-PHENYL)PROPANOIC+ACID'>FLR</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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{{STRUCTURE_3r94| PDB=3r94 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r94 OCA], [https://pdbe.org/3r94 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r94 RCSB], [https://www.ebi.ac.uk/pdbsum/3r94 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r94 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
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===AKR1C3 complex with flurbiprofen===
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==See Also==
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*[[Prostaglandin F synthase 3D structures|Prostaglandin F synthase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3r94]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R94 OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Flanagan, J U.]]
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[[Category: Large Structures]]
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[[Category: Squire, C J.]]
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[[Category: Flanagan JU]]
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[[Category: Teague, R M.]]
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[[Category: Squire CJ]]
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[[Category: Yosaatmadja, Y.]]
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[[Category: Teague RM]]
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[[Category: Flurbiprofen]]
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[[Category: Yosaatmadja Y]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Tim barrel]]
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Current revision

AKR1C3 complex with flurbiprofen

PDB ID 3r94

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