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4eb4

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[[Image:4eb4.jpg|left|200px]]
 
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==Crystal structure of mouse thymidylate synthase in ternary complex with dUMP and Tomudex==
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The line below this paragraph, containing "STRUCTURE_4eb4", creates the "Structure Box" on the page.
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<StructureSection load='4eb4' size='340' side='right'caption='[[4eb4]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4eb4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EB4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EB4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D16:TOMUDEX'>D16</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
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{{STRUCTURE_4eb4| PDB=4eb4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eb4 OCA], [https://pdbe.org/4eb4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eb4 RCSB], [https://www.ebi.ac.uk/pdbsum/4eb4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eb4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TYSY_MOUSE TYSY_MOUSE] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway (By similarity).
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===Crystal structure of mouse thymidylate synthase in ternary complex with dUMP and Tomudex===
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==See Also==
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*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[4eb4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EB4 OCA].
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Thymidylate synthase]]
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[[Category: Dowiercial A]]
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[[Category: Dowiercial, A.]]
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[[Category: Jarmula A]]
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[[Category: Jarmula, A.]]
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[[Category: Rode W]]
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[[Category: Rode, W.]]
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[[Category: Rypniewski WR]]
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[[Category: Rypniewski, W R.]]
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[[Category: Wilk P]]
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[[Category: Wilk, P.]]
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[[Category: Methyltransferase]]
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[[Category: Nucleotide biosynthesis]]
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[[Category: Ternary complex]]
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[[Category: Transferase]]
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Current revision

Crystal structure of mouse thymidylate synthase in ternary complex with dUMP and Tomudex

PDB ID 4eb4

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