4dk8

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[[Image:4dk8.png|left|200px]]
 
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==Crystal structure of LXR ligand binding domain in complex with partial agonist 5==
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The line below this paragraph, containing "STRUCTURE_4dk8", creates the "Structure Box" on the page.
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<StructureSection load='4dk8' size='340' side='right'caption='[[4dk8]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4dk8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DK8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DK8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0KT:N-METHYL-N-(4-{(1S)-2,2,2-TRIFLUORO-1-HYDROXY-1-[1-(2-METHOXYETHYL)-1H-PYRROL-2-YL]ETHYL}PHENYL)BENZENESULFONAMIDE'>0KT</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_4dk8| PDB=4dk8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dk8 OCA], [https://pdbe.org/4dk8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dk8 RCSB], [https://www.ebi.ac.uk/pdbsum/4dk8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dk8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NR1H2_HUMAN NR1H2_HUMAN] Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).
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===Crystal structure of LXR ligand binding domain in complex with partial agonist 5===
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==See Also==
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*[[Liver X receptor|Liver X receptor]]
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 22406115 is the PubMed ID number.
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{{ABSTRACT_PUBMED_22406115}}
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==About this Structure==
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[[4dk8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DK8 OCA].
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==Reference==
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<ref group="xtra">PMID:022406115</ref><references group="xtra"/>
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[[Category: Histone acetyltransferase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Kopecky, D J.]]
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[[Category: Large Structures]]
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[[Category: Piper, D E.]]
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[[Category: Kopecky DJ]]
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[[Category: Xu, H.]]
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[[Category: Piper DE]]
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[[Category: Ligand binding domain]]
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[[Category: Xu H]]
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[[Category: Nuclear hormone receptor]]
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[[Category: Transcription-peptide-agonist complex]]
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Current revision

Crystal structure of LXR ligand binding domain in complex with partial agonist 5

PDB ID 4dk8

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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