2lp8

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[[Image:2lp8.png|left|200px]]
 
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==SOLUTION STRUCTURE OF AN APOPTOSIS ACTIVATING PHOTOSWITCHABLE BAK PEPTIDE BOUND to BCL-XL==
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<StructureSection load='2lp8' size='340' side='right'caption='[[2lp8]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2lp8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LP8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=33B:3,3-(E)-DIAZENE-1,2-DIYLBIS{6-[(CHLOROACETYL)AMINO]BENZENESULFONIC+ACID}'>33B</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lp8 OCA], [https://pdbe.org/2lp8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lp8 RCSB], [https://www.ebi.ac.uk/pdbsum/2lp8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lp8 ProSAT]</span></td></tr>
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{{STRUCTURE_2lp8| PDB=2lp8 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The Bcl-2 family of proteins includes the major regulators and effectors of the intrinsic apoptosis pathway. Cancers are frequently formed when activation of the apoptosis mechanism is compromised either by misregulated expression of prosurvival family members or, more frequently, by damage to the regulatory pathways that trigger intrinsic apoptosis. Short peptides derived from the pro-apoptotic members of the Bcl-2 family can activate mechanisms that ultimately lead to cell death. The recent development of photocontrolled peptides that are able to change their conformation and activity upon irradiation with an external light source has provided new tools to target cells for apoptosis induction with temporal and spatial control. Here, we report the first NMR solution structure of a photoswitchable peptide derived from the proapoptotic protein Bak in complex with the antiapoptotic protein Bcl-x(L). This structure provides insight into the molecular mechanism, by which the increased affinity of such photopeptides compared to their native forms is achieved, and offers a rationale for the large differences in the binding affinities between the helical and nonhelical states.
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===SOLUTION STRUCTURE OF AN APOPTOSIS ACTIVATING PHOTOSWITCHABLE BAK PEPTIDE BOUND to BCL-XL===
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NMR Solution Structure of a Photoswitchable Apoptosis Activating Bak Peptide Bound to Bcl-x(L).,Wysoczanski P, Mart RJ, Loveridge EJ, Williams C, Whittaker SB, Crump MP, Allemann RK J Am Chem Soc. 2012 Apr 25. PMID:22515821<ref>PMID:22515821</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2lp8" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22515821 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22515821}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2lp8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LP8 OCA].
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==Reference==
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<ref group="xtra">PMID:022515821</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Allemann, R K.]]
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[[Category: Large Structures]]
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[[Category: Crump, M P.]]
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[[Category: Allemann RK]]
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[[Category: Loveridge, J E.]]
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[[Category: Crump MP]]
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[[Category: Mart, R J.]]
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[[Category: Loveridge JE]]
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[[Category: Whittaker, S B.M.]]
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[[Category: Mart RJ]]
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[[Category: Williams, C.]]
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[[Category: Whittaker SB-M]]
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[[Category: Wysoczanski, P.]]
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[[Category: Williams C]]
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[[Category: Apoptosis]]
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[[Category: Wysoczanski P]]
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[[Category: Apoptosis inhibitor]]
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[[Category: Apoptosis-apoptosis activator complex]]
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[[Category: Azobenzene]]
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[[Category: Photocontrol]]
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[[Category: Photoswitch]]
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Current revision

SOLUTION STRUCTURE OF AN APOPTOSIS ACTIVATING PHOTOSWITCHABLE BAK PEPTIDE BOUND to BCL-XL

PDB ID 2lp8

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