2lpc

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[[Image:2lpc.png|left|200px]]
 
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==NMR STRUCTURE of Bcl-XL==
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The line below this paragraph, containing "STRUCTURE_2lpc", creates the "Structure Box" on the page.
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<StructureSection load='2lpc' size='340' side='right'caption='[[2lpc]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2lpc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LPC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LPC FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lpc OCA], [https://pdbe.org/2lpc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lpc RCSB], [https://www.ebi.ac.uk/pdbsum/2lpc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lpc ProSAT]</span></td></tr>
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{{STRUCTURE_2lpc| PDB=2lpc | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The Bcl-2 family of proteins includes the major regulators and effectors of the intrinsic apoptosis pathway. Cancers are frequently formed when activation of the apoptosis mechanism is compromised either by misregulated expression of prosurvival family members or, more frequently, by damage to the regulatory pathways that trigger intrinsic apoptosis. Short peptides derived from the pro-apoptotic members of the Bcl-2 family can activate mechanisms that ultimately lead to cell death. The recent development of photocontrolled peptides that are able to change their conformation and activity upon irradiation with an external light source has provided new tools to target cells for apoptosis induction with temporal and spatial control. Here, we report the first NMR solution structure of a photoswitchable peptide derived from the proapoptotic protein Bak in complex with the antiapoptotic protein Bcl-x(L). This structure provides insight into the molecular mechanism, by which the increased affinity of such photopeptides compared to their native forms is achieved, and offers a rationale for the large differences in the binding affinities between the helical and nonhelical states.
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===NMR STRUCTURE of Bcl-XL===
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NMR Solution Structure of a Photoswitchable Apoptosis Activating Bak Peptide Bound to Bcl-x(L).,Wysoczanski P, Mart RJ, Loveridge EJ, Williams C, Whittaker SB, Crump MP, Allemann RK J Am Chem Soc. 2012 Apr 25. PMID:22515821<ref>PMID:22515821</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2lpc" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_22515821}}, adds the Publication Abstract to the page
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22515821 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22515821}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2lpc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LPC OCA].
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==Reference==
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<ref group="xtra">PMID:022515821</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Allemann, R K.]]
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[[Category: Large Structures]]
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[[Category: Crump, M P.]]
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[[Category: Allemann RK]]
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[[Category: Loveridge, J E.]]
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[[Category: Crump MP]]
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[[Category: Mart, R J.]]
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[[Category: Loveridge JE]]
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[[Category: Whittaker, S B.M.]]
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[[Category: Mart RJ]]
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[[Category: Williams, C.]]
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[[Category: Whittaker SB-M]]
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[[Category: Wysoczanski, P.]]
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[[Category: Williams C]]
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[[Category: Apoptosis]]
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[[Category: Wysoczanski P]]
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[[Category: Apoptosis inhibitor]]
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Current revision

NMR STRUCTURE of Bcl-XL

PDB ID 2lpc

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