1n8j

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1n8j" [edit=sysop:move=sysop])
Current revision (09:17, 16 August 2023) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1n8j.png|left|200px]]
 
-
<!--
+
==Crystal Structure of AhpC with Active Site Cysteine mutated to Serine (C46S)==
-
The line below this paragraph, containing "STRUCTURE_1n8j", creates the "Structure Box" on the page.
+
<StructureSection load='1n8j' size='340' side='right'caption='[[1n8j]], [[Resolution|resolution]] 2.17&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1n8j]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N8J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N8J FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.17&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n8j OCA], [https://pdbe.org/1n8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n8j RCSB], [https://www.ebi.ac.uk/pdbsum/1n8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n8j ProSAT]</span></td></tr>
-
{{STRUCTURE_1n8j| PDB=1n8j | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/AHPC_SALTY AHPC_SALTY] Directly reduces alkyl hydroperoxides with the use of electrons donated by the 57 kDa flavoprotein alkyl hydroperoxide reductase.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n8/1n8j_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n8j ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Eukaryotic 2-Cys peroxiredoxins (2-Cys Prxs) not only act as antioxidants, but also appear to regulate hydrogen peroxide-mediated signal transduction. We show that bacterial 2-Cys Prxs are much less sensitive to oxidative inactivation than are eukaryotic 2-Cys Prxs. By identifying two sequence motifs unique to the sensitive 2-Cys Prxs and comparing the crystal structure of a bacterial 2-Cys Prx at 2.2 angstrom resolution with other Prx structures, we define the structural origins of sensitivity. We suggest this adaptation allows 2-Cys Prxs to act as floodgates, keeping resting levels of hydrogen peroxide low, while permitting higher levels during signal transduction.
-
===Crystal Structure of AhpC with Active Site Cysteine mutated to Serine (C46S)===
+
Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling.,Wood ZA, Poole LB, Karplus PA Science. 2003 Apr 25;300(5619):650-3. PMID:12714747<ref>PMID:12714747</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_12714747}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 1n8j" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 12714747 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_12714747}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
[[1n8j]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N8J OCA].
+
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
-
 
+
[[Category: Karplus PA]]
-
==Reference==
+
[[Category: Poole LB]]
-
<ref group="xtra">PMID:012714747</ref><references group="xtra"/>
+
[[Category: Wood ZA]]
-
[[Category: Peroxiredoxin]]
+
-
[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
+
-
[[Category: Karplus, P A.]]
+
-
[[Category: Poole, L B.]]
+
-
[[Category: Wood, Z A.]]
+
-
[[Category: Ahpc]]
+
-
[[Category: Ahpf]]
+
-
[[Category: Alkylhydroperoxide reductase]]
+
-
[[Category: Antioxidant]]
+
-
[[Category: Decamer]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: Peroxidase]]
+
-
[[Category: Peroxiredoxin]]
+

Current revision

Crystal Structure of AhpC with Active Site Cysteine mutated to Serine (C46S)

PDB ID 1n8j

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1n8j"
Personal tools