1wae

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[[Image:1wae.png|left|200px]]
 
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==Crystal structure of H129V Mutant of Alcaligenes Xylosoxidans Nitrite Reductase==
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The line below this paragraph, containing "STRUCTURE_1wae", creates the "Structure Box" on the page.
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<StructureSection load='1wae' size='340' side='right'caption='[[1wae]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wae]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Achromobacter_xylosoxidans Achromobacter xylosoxidans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WAE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WAE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1wae| PDB=1wae | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wae OCA], [https://pdbe.org/1wae PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wae RCSB], [https://www.ebi.ac.uk/pdbsum/1wae PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wae ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O68601_ALCXX O68601_ALCXX]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wa/1wae_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wae ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Copper nitrite reductases contain both an electron-transfer type 1 Cu site and a catalytic type 2 Cu site. We have mutated one of the type 2 copper ligating histidines to observe the effect on catalytic turnover. This mutation has created a unique site where Cu is ligated by 2 His Nepsilon2 atoms alone.
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===Crystal structure of H129V Mutant of Alcaligenes Xylosoxidans Nitrite Reductase===
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Observation of an unprecedented Cu Bis-His site: crystal structure of the H129V mutant of nitrite reductase.,Ellis MJ, Antonyuk SV, Strange RW, Sawers G, Eady RR, Hasnain SS Inorg Chem. 2004 Nov 29;43(24):7591-3. PMID:15554622<ref>PMID:15554622</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15554622}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1wae" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15554622 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15554622}}
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==About this Structure==
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[[1wae]] is a 1 chain structure of [[Nitric reductase]] with sequence from [http://en.wikipedia.org/wiki/Achromobacter_xylosoxidans Achromobacter xylosoxidans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WAE OCA].
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==See Also==
==See Also==
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*[[Nitric reductase|Nitric reductase]]
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*[[Nitrite reductase 3D structures|Nitrite reductase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:015554622</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Achromobacter xylosoxidans]]
[[Category: Achromobacter xylosoxidans]]
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[[Category: Antonyuk, S V.]]
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[[Category: Large Structures]]
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[[Category: Eady, R R.]]
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[[Category: Antonyuk SV]]
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[[Category: Ellis, M J.]]
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[[Category: Eady RR]]
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[[Category: Hasnain, S S.]]
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[[Category: Ellis MJ]]
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[[Category: Sawers, G.]]
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[[Category: Hasnain SS]]
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[[Category: Strange, R W.]]
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[[Category: Sawers G]]
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[[Category: Copper protein]]
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[[Category: Strange RW]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal structure of H129V Mutant of Alcaligenes Xylosoxidans Nitrite Reductase

PDB ID 1wae

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