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4ey7
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4ey7 is ON HOLD Authors: Cheung, J., Rudolph, M., Burshteyn, F., Cassidy, M., Gary, E., Love, J., Height, J., Franklin, M. Description: Crystal Str...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with Donepezil== | |
| + | <StructureSection load='4ey7' size='340' side='right'caption='[[4ey7]], [[Resolution|resolution]] 2.35Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4ey7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EY7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EY7 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3509Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E20:1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE'>E20</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ey7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ey7 OCA], [https://pdbe.org/4ey7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ey7 RCSB], [https://www.ebi.ac.uk/pdbsum/4ey7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ey7 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ACES_HUMAN ACES_HUMAN] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.<ref>PMID:2714437</ref> <ref>PMID:1748670</ref> <ref>PMID:1517212</ref> <ref>PMID:11985878</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Acetylcholinesterase 3D structures|Acetylcholinesterase 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Burshteyn F]] | ||
| + | [[Category: Cassidy M]] | ||
| + | [[Category: Cheung J]] | ||
| + | [[Category: Franklin M]] | ||
| + | [[Category: Gary E]] | ||
| + | [[Category: Height J]] | ||
| + | [[Category: Love J]] | ||
| + | [[Category: Rudolph M]] | ||
Current revision
Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with Donepezil
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Categories: Homo sapiens | Large Structures | Burshteyn F | Cassidy M | Cheung J | Franklin M | Gary E | Height J | Love J | Rudolph M
