4eyf
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4eyf is ON HOLD Authors: Strynadka, N.C.J., King, D.T. Description: Hydrolase 1e) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of NDM-1 bound to hydrolyzed benzylpenicillin== | |
| + | <StructureSection load='4eyf' size='340' side='right'caption='[[4eyf]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4eyf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EYF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EYF FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PNK:(2R,4S)-2-{(R)-CARBOXY[(PHENYLACETYL)AMINO]METHYL}-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>PNK</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eyf OCA], [https://pdbe.org/4eyf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eyf RCSB], [https://www.ebi.ac.uk/pdbsum/4eyf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eyf ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin. | ||
| - | + | ==See Also== | |
| - | + | *[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Klebsiella pneumoniae]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: King DT]] | ||
| + | [[Category: Strynadka NCJ]] | ||
Current revision
Crystal structure of NDM-1 bound to hydrolyzed benzylpenicillin
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