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3sfu

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[[Image:3sfu.jpg|left|200px]]
 
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==crystal structure of murine norovirus RNA dependent RNA polymerase in complex with ribavirin==
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The line below this paragraph, containing "STRUCTURE_3sfu", creates the "Structure Box" on the page.
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<StructureSection load='3sfu' size='340' side='right'caption='[[3sfu]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3sfu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Murine_norovirus_1 Murine norovirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SFU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RBV:1-(BETA-D-RIBOFURANOSYL)-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE'>RBV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3nah|3nah]], [[3nai|3nai]], [[3qid|3qid]], [[3sfg|3sfg]]</div></td></tr>
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{{STRUCTURE_3sfu| PDB=3sfu | SCENE= }}
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RdRp ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=223997 Murine norovirus 1])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sfu OCA], [https://pdbe.org/3sfu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sfu RCSB], [https://www.ebi.ac.uk/pdbsum/3sfu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sfu ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Murine norovirus-1 (MNV-1) shares many features with human norovirus (HuNoV) and both are classified within the norovirus genus of Caliciviridae family. MNV-1 is used as the surrogate for HuNoV research since it is the only form that can be grown in cell culture. HuNoV and MNV-1 RNA dependent RNA polymerase (RdRp) proteins with the sequence identity of 59% show essentially identical conformations. Here we report the first structural evidence of 2-thiouridine (2TU) or ribavirin binding to MNV-1 RdRp, based on the crystal structures determined at 2.2A and 2.5A resolutions, respectively. Cellular and biochemical studies revealed stronger inhibitory effect of 2TU on the replication of MNV-1 in RAW 264.7 cells, compared to that of ribavirin. Our complex structures highlight the key interactions involved in recognition of the nucleoside analogs which block the active site of the viral RNA polymerase.
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===crystal structure of murine norovirus RNA dependent RNA polymerase in complex with ribavirin===
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Crystal structures of murine norovirus-1 RNA-dependent RNA polymerase in complex with 2-thiouridine or ribavirin.,Alam I, Lee JH, Cho KJ, Han KR, Yang JM, Chung MS, Kim KH Virology. 2012 May 10;426(2):143-51. Epub 2012 Feb 16. PMID:22341781<ref>PMID:22341781</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3sfu" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_22341781}}, adds the Publication Abstract to the page
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22341781 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22341781}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3sfu]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Murine_norovirus_1 Murine norovirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SFU OCA].
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==Reference==
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<ref group="xtra">PMID:022341781</ref><references group="xtra"/>
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[[Category: Murine norovirus 1]]
[[Category: Murine norovirus 1]]
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[[Category: Alam, I.]]
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[[Category: Alam, I]]
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[[Category: Kim, K H.]]
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[[Category: Kim, K H]]
[[Category: Right handed fold]]
[[Category: Right handed fold]]
[[Category: Rna binding]]
[[Category: Rna binding]]
[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Viral replication enzyme]]
[[Category: Viral replication enzyme]]

Current revision

crystal structure of murine norovirus RNA dependent RNA polymerase in complex with ribavirin

PDB ID 3sfu

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