3rkq

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[[Image:3rkq.jpg|left|200px]]
 
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==NKX2.5 Homeodomain dimer bound to ANF-242 DNA==
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The line below this paragraph, containing "STRUCTURE_3rkq", creates the "Structure Box" on the page.
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<StructureSection load='3rkq' size='340' side='right'caption='[[3rkq]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3rkq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RKQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RKQ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_3rkq| PDB=3rkq | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rkq OCA], [https://pdbe.org/3rkq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rkq RCSB], [https://www.ebi.ac.uk/pdbsum/3rkq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rkq ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/NKX25_HUMAN NKX25_HUMAN] Athyreosis;Familial isolated congenital asplenia;Atrial septal defect - atrioventricular conduction defects;Atrial septal defect, ostium secundum type;Hypoplastic left heart syndrome;Tetralogy of Fallot;Familial atrial fibrillation;Familial progressive cardiac conduction defect;Thyroid hypoplasia;Ventricular septal defect. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/NKX25_HUMAN NKX25_HUMAN] Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4 (By similarity). It is transcriptionally controlled by PBX1 and acts as a transcriptional repressor of CDKN2B (By similarity). It is required for spleen development.<ref>PMID:22560297</ref>
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===NKX2.5 Homeodomain dimer bound to ANF-242 DNA===
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==See Also==
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*[[NKX2.5 Homeodomain|NKX2.5 Homeodomain]]
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== References ==
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==About this Structure==
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<references/>
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[[3rkq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RKQ OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Genis, C.]]
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[[Category: Large Structures]]
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[[Category: Kasahara, H.]]
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[[Category: Genis C]]
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[[Category: Nam, H J.]]
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[[Category: Kasahara H]]
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[[Category: Scone, P.]]
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[[Category: Nam H-J]]
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[[Category: Dna binding]]
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[[Category: Scone P]]
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[[Category: Helix-turn-helix]]
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[[Category: Nucleus]]
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[[Category: Transcription-dna complex]]
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Current revision

NKX2.5 Homeodomain dimer bound to ANF-242 DNA

PDB ID 3rkq

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