Penicillopepsin

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<StructureSection load='1ppm' size='400' side='right' scene='49/493723/Cv/1' caption='Glycosylated penicillopepsin complex with peptide analog and sulfate, [[1ppm]]' pspeed='8'>
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'''Penicillopepsin''' (PP) is a proteinase with a broad spectrum of substrates. PP prefers hydrophobic residues at P1 and P1’ sites. PP causes clotting in milk and activates trypsinogen. PP is a member of the aspartic proteinase family. Its extended binding site cleft can bind at least 7 amino acids.
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== Function ==
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'''Penicillopepsin''' (PP) is a proteinase with a broad spectrum of substrates. PP prefers hydrophobic residues at P1 and P1’ sites. PP is a member of the aspartic proteinase family. Its extended binding site cleft can bind at least 7 amino acids<ref>PMID:1172664</ref>.
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== Relevance ==
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PP causes clotting in milk and activates trypsinogen.
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== Structural highlights ==
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*<scene name='49/493723/Cv/3'>Binding site</scene>.
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*<scene name='49/493723/Cv/4'>Binding site cleft</scene>.
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</StructureSection>
==3D structures of penicillopepsin==
==3D structures of penicillopepsin==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
[[3app]] – PjPP – ''Penicillium janthinellum''<br />
[[3app]] – PjPP – ''Penicillium janthinellum''<br />
[[1ppl]], [[1ppm]], [[1ppk]] – PjPP + peptide analog<br />
[[1ppl]], [[1ppm]], [[1ppk]] – PjPP + peptide analog<br />
[[1apt]], [[1apu]], [[1apv]], [[1apw]] - PjPP + pepstatin analog<br />
[[1apt]], [[1apu]], [[1apv]], [[1apw]] - PjPP + pepstatin analog<br />
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[[2wea]], [[2web]], [[2wec]], [[2wed]], [[1bxo]], [[1bxq]] - PjPP + peptidyl inhibitor
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[[2wea]], [[2web]], [[2wec]], [[2wed]], [[1bxo]], [[1bxq]] - PjPP + peptidyl inhibitor<br />
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== References ==
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<references/>
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[[Category:Topic Page]]

Current revision

Glycosylated penicillopepsin complex with peptide analog and sulfate, 1ppm

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3D structures of penicillopepsin

Updated on 18-July-2024

3app – PjPP – Penicillium janthinellum
1ppl, 1ppm, 1ppk – PjPP + peptide analog
1apt, 1apu, 1apv, 1apw - PjPP + pepstatin analog
2wea, 2web, 2wec, 2wed, 1bxo, 1bxq - PjPP + peptidyl inhibitor

References

  1. ↑ Takahashi M, Hofmann T. Acyl intermediates in penicillopepsin-catalysed reactions and a discussion of the mechanism of action of pepsins. Biochem J. 1975 Jun;147(3):549-63. PMID:1172664

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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