4ekc
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human regulator of G protein signaling 2 (RGS2) in complex with murine Galpha-q(R183C)== | |
| + | <StructureSection load='4ekc' size='340' side='right'caption='[[4ekc]], [[Resolution|resolution]] 7.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4ekc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EKC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EKC FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 7.4Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ekc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ekc OCA], [https://pdbe.org/4ekc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ekc RCSB], [https://www.ebi.ac.uk/pdbsum/4ekc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ekc ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GNAQ_MOUSE GNAQ_MOUSE] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro).<ref>PMID:17938235</ref> <ref>PMID:20624888</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Regulator of G-protein signaling 3D structures|Regulator of G-protein signaling 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Nance MR]] | ||
| + | [[Category: Tesmer JJG]] | ||
Current revision
Structure of human regulator of G protein signaling 2 (RGS2) in complex with murine Galpha-q(R183C)
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