4f2j
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of ZNF217 bound to DNA, P6522 crystal form== | |
| - | + | <StructureSection load='4f2j' size='340' side='right'caption='[[4f2j]], [[Resolution|resolution]] 2.64Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4f2j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F2J FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.64Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f2j OCA], [https://pdbe.org/4f2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f2j RCSB], [https://www.ebi.ac.uk/pdbsum/4f2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f2j ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ZN217_HUMAN ZN217_HUMAN] Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.<ref>PMID:16203743</ref> <ref>PMID:17259635</ref> <ref>PMID:18625718</ref> <ref>PMID:16940172</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Guss JM]] | ||
| + | [[Category: Jacques DA]] | ||
| + | [[Category: Mackay JP]] | ||
| + | [[Category: Vandevenne MS]] | ||
Current revision
Crystal structure of ZNF217 bound to DNA, P6522 crystal form
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