This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4dra

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:48, 20 March 2024) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:4dra.jpg|left|200px]]
 
-
<!--
+
==Crystal structure of MHF complex==
-
The line below this paragraph, containing "STRUCTURE_4dra", creates the "Structure Box" on the page.
+
<StructureSection load='4dra' size='340' side='right'caption='[[4dra]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[4dra]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DRA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DRA FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.414&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dra FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dra OCA], [https://pdbe.org/4dra PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dra RCSB], [https://www.ebi.ac.uk/pdbsum/4dra PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dra ProSAT]</span></td></tr>
-
{{STRUCTURE_4dra| PDB=4dra | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CENPS_HUMAN CENPS_HUMAN] DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Required for optimal chromatin association of the FA core complex. Required for efficient damage-induced monoubiquitination and focus formation of FANCD2. Stabilizes FAAD24, FANCM and STRA13/CENPX in the FA core complex. Plays a role in DNA interstrand cross-linking (ICL) repair and in recovery of replication forks stalled by topoisomerase I-DNA cleavage intermediates induced by camptothecin. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. Component of the APITD1/CENPS complex that is essential for the stable assembly of the outer kinetochore. Plays an important role in mitotic progression and chromosome segregation. Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.<ref>PMID:19620631</ref> <ref>PMID:22814378</ref> [REFERENCE:8]
-
===Crystal structure of MHF complex===
+
==See Also==
-
 
+
*[[Centromere protein 3D structure|Centromere protein 3D structure]]
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_22510687}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 22510687 is the PubMed ID number.
+
</StructureSection>
-
-->
+
-
{{ABSTRACT_PUBMED_22510687}}
+
-
 
+
-
==About this Structure==
+
-
[[4dra]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DRA OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:022510687</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Niu, L.]]
+
[[Category: Large Structures]]
-
[[Category: Tao, Y.]]
+
[[Category: Niu L]]
-
[[Category: Teng, M.]]
+
[[Category: Tao Y]]
-
[[Category: Dna binding complex]]
+
[[Category: Teng M]]
-
[[Category: Dna binding protein]]
+
-
[[Category: Dna damage repair]]
+
-
[[Category: Histone-fold]]
+

Current revision

Crystal structure of MHF complex

PDB ID 4dra

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4dra"
Personal tools