4dny

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[[Image:4dny.jpg|left|200px]]
 
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==Crystal structure of enterohemorrhagic E. coli StcE(132-251)==
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The line below this paragraph, containing "STRUCTURE_4dny", creates the "Structure Box" on the page.
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<StructureSection load='4dny' size='340' side='right'caption='[[4dny]], [[Resolution|resolution]] 1.61&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4dny]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DNY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.61&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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{{STRUCTURE_4dny| PDB=4dny | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dny OCA], [https://pdbe.org/4dny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dny RCSB], [https://www.ebi.ac.uk/pdbsum/4dny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dny ProSAT]</span></td></tr>
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</table>
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===Crystal structure of enterohemorrhagic E. coli StcE(132-251)===
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== Function ==
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[https://www.uniprot.org/uniprot/STCE_ECO57 STCE_ECO57] Virulence factor that contributes to intimate adherence of enterohemorrhagic E.coli (EHEC) O157:H7 to host cells. Is able to cleave the secreted human mucin 7 (MUC7) and the glycoprotein 340 (DMBT1/GP340). Also cleaves human C1 inhibitor (SERPING1), a regulator of multiple inflammatory pathways, and binds and localizes it to bacterial and host cell surfaces, protecting them from complement-mediated lysis. Therefore, the current model proposes two roles for StcE during infection: it acts first as a mucinase, allowing passage of EHEC through the oral cavity by cleaving the salivary glycoproteins that are responsible for bacterial aggregation. Similarly, in the colon, StcE cleaves the glycoproteins that protect the intestinal epithelial surface, allowing EHEC to come into close contact with host cell membranes. Secondly, it acts as an anti-inflammatory agent by localizing SERPING1 to cell membranes.<ref>PMID:15731026</ref> <ref>PMID:12123444</ref> <ref>PMID:15096536</ref> <ref>PMID:16788173</ref>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22483117}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22483117 is the PubMed ID number.
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</StructureSection>
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[[Category: Escherichia coli O157:H7]]
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{{ABSTRACT_PUBMED_22483117}}
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[[Category: Large Structures]]
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[[Category: Strynadka NCJ]]
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==About this Structure==
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[[Category: Yu ACY]]
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[[4dny]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DNY OCA].
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==Reference==
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<ref group="xtra">PMID:022483117</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
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[[Category: Strynadka, N C.J.]]
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[[Category: Yu, A C.Y.]]
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[[Category: Bacterial zinc metalloprotease]]
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[[Category: Hydrolase]]
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[[Category: Metzincin]]
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[[Category: O-linked glycoprotein]]
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Current revision

Crystal structure of enterohemorrhagic E. coli StcE(132-251)

PDB ID 4dny

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