4drb

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[[Image:4drb.jpg|left|200px]]
 
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==The crystal structure of FANCM bound MHF complex==
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The line below this paragraph, containing "STRUCTURE_4drb", creates the "Structure Box" on the page.
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<StructureSection load='4drb' size='340' side='right'caption='[[4drb]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4drb]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DRB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DRB FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.634&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_4drb| PDB=4drb | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4drb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4drb OCA], [https://pdbe.org/4drb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4drb RCSB], [https://www.ebi.ac.uk/pdbsum/4drb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4drb ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CENPS_HUMAN CENPS_HUMAN] DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Required for optimal chromatin association of the FA core complex. Required for efficient damage-induced monoubiquitination and focus formation of FANCD2. Stabilizes FAAD24, FANCM and STRA13/CENPX in the FA core complex. Plays a role in DNA interstrand cross-linking (ICL) repair and in recovery of replication forks stalled by topoisomerase I-DNA cleavage intermediates induced by camptothecin. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. Component of the APITD1/CENPS complex that is essential for the stable assembly of the outer kinetochore. Plays an important role in mitotic progression and chromosome segregation. Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.<ref>PMID:19620631</ref> <ref>PMID:22814378</ref> [REFERENCE:8]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Fanconi anaemia is a rare genetic disease characterized by chromosomal instability and cancer susceptibility. The Fanconi anaemia complementation group protein M (FANCM) forms an evolutionarily conserved DNA-processing complex with MHF1/MHF2 (histone-fold-containing proteins), which is essential for DNA repair in response to genotoxic stress. Here we present the crystal structures of the MHF1-MHF2 complex alone and bound to a fragment of FANCM (FANCM(661-800), designated FANCM-F). The structures show that MHF1 and MHF2 form a compact tetramer to which FANCM-F binds through a 'dual-V' shaped structure. FANCM-F and (MHF1-MHF2)(2) cooperate to constitute a new DNA-binding site that is coupled to the canonical L1L2 region. Perturbation of the MHF-FANCM-F structural plasticity changes the localization of FANCM in vivo. The MHF-FANCM interaction and its subcellular localization are altered by a disease-associated mutant of FANCM. These findings reveal the molecular basis of MHF-FANCM recognition and provide mechanistic insights into the pathway leading to Fanconi anaemia.
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===The crystal structure of FANCM bound MHF complex===
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The structure of the FANCM-MHF complex reveals physical features for functional assembly.,Tao Y, Jin C, Li X, Qi S, Chu L, Niu L, Yao X, Teng M Nat Commun. 2012 Apr 17;3:782. doi: 10.1038/ncomms1779. PMID:22510687<ref>PMID:22510687</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4drb" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Centromere protein 3D structure|Centromere protein 3D structure]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22510687 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22510687}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[4drb]] is a 15 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DRB OCA].
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==Reference==
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<ref group="xtra">PMID:022510687</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Niu, L.]]
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[[Category: Large Structures]]
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[[Category: Tao, Y.]]
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[[Category: Niu L]]
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[[Category: Teng, M.]]
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[[Category: Tao Y]]
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[[Category: Dna binding]]
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[[Category: Teng M]]
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[[Category: Dna binding complex]]
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[[Category: Dna binding protein-protein binding complex]]
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[[Category: Dna binding-protein binding complex]]
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[[Category: Dna damage repair]]
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[[Category: Dna repair]]
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[[Category: Histone fold]]
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Current revision

The crystal structure of FANCM bound MHF complex

PDB ID 4drb

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