4apw

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[[Image:4apw.jpg|left|200px]]
 
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==Alp12 filament structure==
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The line below this paragraph, containing "STRUCTURE_4apw", creates the "Structure Box" on the page.
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<SX load='4apw' size='340' side='right' viewer='molstar' caption='[[4apw]], [[Resolution|resolution]] 19.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4apw]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4APW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4APW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 19.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4apw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4apw OCA], [https://pdbe.org/4apw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4apw RCSB], [https://www.ebi.ac.uk/pdbsum/4apw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4apw ProSAT]</span></td></tr>
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{{STRUCTURE_4apw| PDB=4apw | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q89A01_CLOTE Q89A01_CLOTE]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Eukaryotic F-actin is constructed from two protofilaments that gently wind around each other to form a helical polymer. Several bacterial actin-like proteins (Alps) are also known to form F-actin-like helical arrangements from two protofilaments, yet with varied helical geometries. Here, we report a unique filament architecture of Alp12 from Clostridium tetani that is constructed from four protofilaments. Through fitting of an Alp12 monomer homology model into the electron microscopy data, the filament was determined to be constructed from two antiparallel strands, each composed of two parallel protofilaments. These four protofilaments form an open helical cylinder separated by a wide cleft. The molecular interactions within single protofilaments are similar to F-actin, yet interactions between protofilaments differ from those in F-actin. The filament structure and assembly and disassembly kinetics suggest Alp12 to be a dynamically unstable force-generating motor involved in segregating the pE88 plasmid, which encodes the lethal tetanus toxin, and thus a potential target for drug design. Alp12 can be repeatedly cycled between states of polymerization and dissociation, making it a novel candidate for incorporation into fuel-propelled nanobiopolymer machines.
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===Alp12 filament structure===
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Novel Actin-like Filament Structure from Clostridium tetani.,Popp D, Narita A, Lee LJ, Ghoshdastider U, Xue B, Srinivasan R, Balasubramanian MK, Tanaka T, Robinson RC J Biol Chem. 2012 Jun 15;287(25):21121-9. Epub 2012 Apr 18. PMID:22514279<ref>PMID:22514279</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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[[4apw]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4APW OCA].
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<div class="pdbe-citations 4apw" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</SX>
[[Category: Clostridium tetani]]
[[Category: Clostridium tetani]]
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[[Category: Balasubramanian, M K.]]
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[[Category: Large Structures]]
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[[Category: Ghoshdastider, U.]]
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[[Category: Balasubramanian MK]]
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[[Category: Lee, L J.]]
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[[Category: Ghoshdastider U]]
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[[Category: Narita, A.]]
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[[Category: Lee LJ]]
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[[Category: Popp, D.]]
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[[Category: Narita A]]
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[[Category: Robinson, R C.]]
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[[Category: Popp D]]
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[[Category: Srinivasan, R.]]
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[[Category: Robinson RC]]
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[[Category: Tanaka, T.]]
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[[Category: Srinivasan R]]
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[[Category: Xue, B.]]
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[[Category: Tanaka T]]
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[[Category: Actin-like protein]]
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[[Category: Xue B]]
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[[Category: Alp12]]
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[[Category: Structural protein]]
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Current revision

Alp12 filament structure

4apw, resolution 19.70Å

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