4ecb

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[[Image:4ecb.jpg|left|200px]]
 
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==Chimeric GST Containing Inserts of Kininogen Peptides==
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The line below this paragraph, containing "STRUCTURE_4ecb", creates the "Structure Box" on the page.
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<StructureSection load='4ecb' size='340' side='right'caption='[[4ecb]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4ecb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Schistosoma_japonicum Schistosoma japonicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ECB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ECB FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ecb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ecb OCA], [https://pdbe.org/4ecb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ecb RCSB], [https://www.ebi.ac.uk/pdbsum/4ecb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ecb ProSAT]</span></td></tr>
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{{STRUCTURE_4ecb| PDB=4ecb | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/KNG1_HUMAN KNG1_HUMAN] Congenital high-molecular-weight kininogen deficiency. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/KNG1_HUMAN KNG1_HUMAN] (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.[https://www.uniprot.org/uniprot/GST26_SCHJA GST26_SCHJA] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.
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===Chimeric GST Containing Inserts of Kininogen Peptides===
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==See Also==
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*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[4ecb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Schistosoma_japonicum,_homo_sapiens Schistosoma japonicum, homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ECB OCA].
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[[Category: Homo sapiens]]
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[[Category: Glutathione transferase]]
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[[Category: Large Structures]]
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[[Category: Schistosoma japonicum, homo sapiens]]
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[[Category: Schistosoma japonicum]]
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[[Category: Amber, A B.]]
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[[Category: Amber AB]]
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[[Category: Anton, A K.]]
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[[Category: Anton AK]]
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[[Category: Keith, R M.]]
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[[Category: Keith RM]]
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[[Category: Marianne, P C.]]
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[[Category: Marianne P-C]]
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[[Category: Rita, R]]
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[[Category: Rita R]]
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[[Category: Sergei, M M.]]
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[[Category: Sergei MM]]
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[[Category: Vivien, Y.]]
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[[Category: Vivien Y]]
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[[Category: William, C M.]]
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[[Category: William CM]]
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[[Category: Xiaoping, Q.]]
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[[Category: Xiaoping Q]]
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[[Category: Yi, P.]]
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[[Category: Yi P]]
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[[Category: Protein binding]]
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[[Category: Transferase]]
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Current revision

Chimeric GST Containing Inserts of Kininogen Peptides

PDB ID 4ecb

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