4ej4

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[[Image:4ej4.jpg|left|200px]]
 
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==Structure of the delta opioid receptor bound to naltrindole==
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The line below this paragraph, containing "STRUCTURE_4ej4", creates the "Structure Box" on the page.
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<StructureSection load='4ej4' size='340' side='right'caption='[[4ej4]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4ej4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EJ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EJ4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EJ4:(4BS,8R,8AS,14BR)-7-(CYCLOPROPYLMETHYL)-5,6,7,8,14,14B-HEXAHYDRO-4,8-METHANO[1]BENZOFURO[2,3-A]PYRIDO[4,3-B]CARBAZOLE-1,8A(9H)-DIOL'>EJ4</scene></td></tr>
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{{STRUCTURE_4ej4| PDB=4ej4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ej4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ej4 OCA], [https://pdbe.org/4ej4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ej4 RCSB], [https://www.ebi.ac.uk/pdbsum/4ej4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ej4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/OPRD_MOUSE OPRD_MOUSE] G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.<ref>PMID:10677041</ref> <ref>PMID:1334555</ref> <ref>PMID:1335167</ref> [https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
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===Structure of the delta opioid receptor bound to naltrindole===
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==See Also==
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*[[Lysozyme 3D structures|Lysozyme 3D structures]]
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*[[Opioid receptor|Opioid receptor]]
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==About this Structure==
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== References ==
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[[4ej4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus,_enterobacteria_phage_t4 Mus musculus, enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EJ4 OCA].
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<references/>
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[[Category: Lysozyme]]
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__TOC__
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[[Category: Mus musculus, enterobacteria phage t4]]
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</StructureSection>
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[[Category: Granier, S.]]
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[[Category: Escherichia virus T4]]
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[[Category: Kobilka, B K.]]
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[[Category: Large Structures]]
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[[Category: Kobilka, T S.]]
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[[Category: Mus musculus]]
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[[Category: Kruse, A C.]]
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[[Category: Granier S]]
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[[Category: Manglik, A.]]
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[[Category: Kobilka BK]]
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[[Category: Thian, F S.]]
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[[Category: Kobilka TS]]
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[[Category: Weis, W I.]]
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[[Category: Kruse AC]]
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[[Category: 7 transmembrane receptor]]
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[[Category: Manglik A]]
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[[Category: G-protein coupled receptor]]
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[[Category: Thian FS]]
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[[Category: Hydrolase-antagonist complex]]
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[[Category: Weis WI]]
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[[Category: Opioid receptor]]
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[[Category: Signaling protein]]
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Current revision

Structure of the delta opioid receptor bound to naltrindole

PDB ID 4ej4

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