4er6

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[[Image:4er6.jpg|left|200px]]
 
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==Crystal structure of human DOT1L in complex with inhibitor SGC0946==
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The line below this paragraph, containing "STRUCTURE_4er6", creates the "Structure Box" on the page.
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<StructureSection load='4er6' size='340' side='right'caption='[[4er6]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4er6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ER6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AW2:5-BROMO-7-{5-[(3-{[(4-TERT-BUTYLPHENYL)CARBAMOYL]AMINO}PROPYL)(PROPAN-2-YL)AMINO]-5-DEOXY-BETA-D-RIBOFURANOSYL}-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE'>AW2</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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{{STRUCTURE_4er6| PDB=4er6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4er6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4er6 OCA], [https://pdbe.org/4er6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4er6 RCSB], [https://www.ebi.ac.uk/pdbsum/4er6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4er6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
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===Crystal structure of human DOT1L in complex with inhibitor SGC0946===
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==See Also==
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*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[4er6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER6 OCA].
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[[Category: Histone-lysine N-methyltransferase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bountra, C.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bradner, J E.]]
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[[Category: Bountra C]]
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[[Category: Brown, P J.]]
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[[Category: Bradner JE]]
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[[Category: Edwards, A M.]]
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[[Category: Brown PJ]]
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[[Category: Li, Y.]]
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[[Category: Edwards AM]]
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[[Category: Nguyen, K T.]]
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[[Category: Li Y]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Nguyen KT]]
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[[Category: Schapira, M.]]
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[[Category: Schapira M]]
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[[Category: Scopton, A.]]
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[[Category: Scopton A]]
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[[Category: Tempel, W.]]
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[[Category: Tempel W]]
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[[Category: Vedadi, M.]]
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[[Category: Vedadi M]]
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[[Category: Wernimont, A K.]]
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[[Category: Wernimont AK]]
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[[Category: Yu, W.]]
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[[Category: Yu W]]
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[[Category: Epigenetic]]
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[[Category: Histone]]
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[[Category: Methyltransferase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Crystal structure of human DOT1L in complex with inhibitor SGC0946

PDB ID 4er6

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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