4er7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:05, 1 March 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:4er7.jpg|left|200px]]
 
-
<!--
+
==Crystal Structure of human DOT1L in complex with inhibitor SGC0947==
-
The line below this paragraph, containing "STRUCTURE_4er7", creates the "Structure Box" on the page.
+
<StructureSection load='4er7' size='340' side='right'caption='[[4er7]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[4er7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ER7 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AW3:5-BROMO-7-{5-[(3-{[(4-TERT-BUTYLPHENYL)CARBAMOYL]AMINO}PROPYL)AMINO]-5-DEOXY-BETA-D-RIBOFURANOSYL}-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE'>AW3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-
{{STRUCTURE_4er7| PDB=4er7 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4er7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4er7 OCA], [https://pdbe.org/4er7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4er7 RCSB], [https://www.ebi.ac.uk/pdbsum/4er7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4er7 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
-
===Crystal Structure of human DOT1L in complex with inhibitor SGC0947===
+
==See Also==
-
 
+
*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
-
 
+
__TOC__
-
==About this Structure==
+
</StructureSection>
-
[[4er7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER7 OCA].
+
-
[[Category: Histone-lysine N-methyltransferase]]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Large Structures]]
-
[[Category: Bountra, C.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Bradner, J E.]]
+
[[Category: Bountra C]]
-
[[Category: Brown, P J.]]
+
[[Category: Bradner JE]]
-
[[Category: Edwards, A M.]]
+
[[Category: Brown PJ]]
-
[[Category: Li, Y.]]
+
[[Category: Edwards AM]]
-
[[Category: Nguyen, K T.]]
+
[[Category: Li Y]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Nguyen KT]]
-
[[Category: Schapira, M.]]
+
[[Category: Schapira M]]
-
[[Category: Scopton, A.]]
+
[[Category: Scopton A]]
-
[[Category: Tempel, W.]]
+
[[Category: Tempel W]]
-
[[Category: Vedadi, M.]]
+
[[Category: Vedadi M]]
-
[[Category: Wernimont, A K.]]
+
[[Category: Wernimont AK]]
-
[[Category: Yu, W.]]
+
[[Category: Yu W]]
-
[[Category: Epigenetic]]
+
-
[[Category: Histone]]
+
-
[[Category: Methyltransferase]]
+
-
[[Category: Transferase-transferase inhibitor complex]]
+

Current revision

Crystal Structure of human DOT1L in complex with inhibitor SGC0947

PDB ID 4er7

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4er7"
Personal tools