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4dro

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[[Image:4dro.png|left|200px]]
 
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==EVALUATION OF SYNTHETIC FK506 ANALOGS AS LIGANDS FOR FKBP51 AND FKBP52: COMPLEX OF FKBP51 WITH (1R)-3-(3,4-dimethoxyphenyl)-1-phenylpropyl (2S)-1-{[(1R,2S)-2-ethyl-1-hydroxycyclohexyl](oxo)acetyl}piperidine-2-carboxylate==
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The line below this paragraph, containing "STRUCTURE_4dro", creates the "Structure Box" on the page.
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<StructureSection load='4dro' size='340' side='right'caption='[[4dro]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4dro]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DRO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DRO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0MD:{3-[(1R)-3-(3,4-DIMETHOXYPHENYL)-1-({[(2S)-1-{[(1R,2S)-2-ETHYL-1-HYDROXYCYCLOHEXYL](OXO)ACETYL}PIPERIDIN-2-YL]CARBONYL}OXY)PROPYL]PHENOXY}ACETIC+ACID'>0MD</scene></td></tr>
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{{STRUCTURE_4dro| PDB=4dro | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dro OCA], [https://pdbe.org/4dro PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dro RCSB], [https://www.ebi.ac.uk/pdbsum/4dro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dro ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FKBP5_HUMAN FKBP5_HUMAN] Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.
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===EVALUATION OF SYNTHETIC FK506 ANALOGS AS LIGANDS FOR FKBP51 AND FKBP52: COMPLEX OF FKBP51 WITH (1R)-3-(3,4-dimethoxyphenyl)-1-phenylpropyl (2S)-1-{[(1R,2S)-2-ethyl-1-hydroxycyclohexyl](oxo)acetyl}piperidine-2-carboxylate===
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==See Also==
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*[[FKBP 3D structures|FKBP 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_22455444}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 22455444 is the PubMed ID number.
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{{ABSTRACT_PUBMED_22455444}}
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==About this Structure==
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[[4dro]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DRO OCA].
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==Reference==
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<ref group="xtra">PMID:022455444</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Large Structures]]
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[[Category: Bracher, A.]]
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[[Category: Bracher A]]
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[[Category: Gaali, S.]]
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[[Category: Gaali S]]
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[[Category: Gopalakrishnan, R.]]
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[[Category: Gopalakrishnan R]]
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[[Category: Hausch, F.]]
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[[Category: Hausch F]]
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[[Category: Hoogeland, B.]]
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[[Category: Hoogeland B]]
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[[Category: Kozany, C.]]
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[[Category: Kozany C]]
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[[Category: Kress, C.]]
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[[Category: Kress C]]
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[[Category: Fk-506 binding domain]]
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[[Category: Hsp90 cochaperone]]
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[[Category: Immunophilin]]
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[[Category: Isomerase]]
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[[Category: Peptidyl-prolyl isomerase]]
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Current revision

EVALUATION OF SYNTHETIC FK506 ANALOGS AS LIGANDS FOR FKBP51 AND FKBP52: COMPLEX OF FKBP51 WITH (1R)-3-(3,4-dimethoxyphenyl)-1-phenylpropyl (2S)-1-{[(1R,2S)-2-ethyl-1-hydroxycyclohexyl](oxo)acetyl}piperidine-2-carboxylate

PDB ID 4dro

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OCA

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