3rvt

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[[Image:3rvt.png|left|200px]]
 
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==Structure of 4C1 Fab in P212121 space group==
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The line below this paragraph, containing "STRUCTURE_3rvt", creates the "Structure Box" on the page.
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<StructureSection load='3rvt' size='340' side='right'caption='[[3rvt]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3rvt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RVT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RVT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rvt OCA], [https://pdbe.org/3rvt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rvt RCSB], [https://www.ebi.ac.uk/pdbsum/3rvt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rvt ProSAT]</span></td></tr>
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{{STRUCTURE_3rvt| PDB=3rvt | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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House dust mites produce potent allergens, Der p 1 and Der f 1, that cause allergic sensitization and asthma. Der p 1 and Der f 1 are cysteine proteases that elicit IgE responses in 80% of mite-allergic subjects and have proinflammatory properties. Their antigenic structure is unknown. Here, we present crystal structures of natural Der p 1 and Der f 1 in complex with a monoclonal antibody, 4C1, which binds to a unique cross-reactive epitope on both allergens associated with IgE recognition. The 4C1 epitope is formed by almost identical amino acid sequences and contact residues. Mutations of the contact residues abrogate mAb 4C1 binding and reduce IgE antibody binding. These surface-exposed residues are molecular targets that can be exploited for development of recombinant allergen vaccines.
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===Structure of 4C1 Fab in P212121 space group===
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Molecular determinants for antibody binding on group 1 house dust mite allergens.,Chruszcz M, Pomes A, Glesner J, Vailes LD, Osinski T, Porebski PJ, Majorek KA, Heymann PW, Platts-Mills TA, Minor W, Chapman MD J Biol Chem. 2012 Mar 2;287(10):7388-98. Epub 2011 Dec 30. PMID:22210776<ref>PMID:22210776</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3rvt" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_22210776}}, adds the Publication Abstract to the page
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*[[Antibody 3D structures|Antibody 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22210776 is the PubMed ID number.
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*[[Sandbox 20009|Sandbox 20009]]
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*[[3D structures of non-human antibody|3D structures of non-human antibody]]
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{{ABSTRACT_PUBMED_22210776}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3rvt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RVT OCA].
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</StructureSection>
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:022210776</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Chapman, M D.]]
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[[Category: Chapman MD]]
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[[Category: Chruszcz, M.]]
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[[Category: Chruszcz M]]
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[[Category: Minor, W.]]
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[[Category: Minor W]]
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[[Category: Pomes, A.]]
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[[Category: Pomes A]]
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[[Category: Vailes, L D.]]
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[[Category: Vailes LD]]
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[[Category: Antibody]]
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[[Category: Der f 1]]
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[[Category: Der p 1]]
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[[Category: Igg]]
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[[Category: Immune system]]
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Current revision

Structure of 4C1 Fab in P212121 space group

PDB ID 3rvt

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