3ufj

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[[Image:3ufj.png|left|200px]]
 
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==Human Thymine DNA Glycosylase Bound to Substrate Analog 2'-fluoro-2'-deoxyuridine==
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The line below this paragraph, containing "STRUCTURE_3ufj", creates the "Structure Box" on the page.
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<StructureSection load='3ufj' size='340' side='right'caption='[[3ufj]], [[Resolution|resolution]] 2.97&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ufj]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UFJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UFJ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.967&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UF2:1-(2-DEOXY-2-FLUORO-5-O-PHOSPHONO-BETA-D-ARABINOFURANOSYL)PYRIMIDINE-2,4(1H,3H)-DIONE'>UF2</scene></td></tr>
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{{STRUCTURE_3ufj| PDB=3ufj | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ufj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ufj OCA], [https://pdbe.org/3ufj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ufj RCSB], [https://www.ebi.ac.uk/pdbsum/3ufj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ufj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TDG_HUMAN TDG_HUMAN] In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. This enzyme corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.
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===Human Thymine DNA Glycosylase Bound to Substrate Analog 2'-fluoro-2'-deoxyuridine===
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==See Also==
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*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_22573813}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 22573813 is the PubMed ID number.
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{{ABSTRACT_PUBMED_22573813}}
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==About this Structure==
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[[3ufj]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UFJ OCA].
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==Reference==
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<ref group="xtra">PMID:022573813</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Thymine-DNA glycosylase]]
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[[Category: Large Structures]]
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[[Category: Drohat, A C.]]
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[[Category: Drohat AC]]
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[[Category: Maiti, A.]]
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[[Category: Maiti A]]
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[[Category: Pozharski, E.]]
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[[Category: Pozharski E]]
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[[Category: Dna binding]]
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[[Category: Dna damage]]
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[[Category: Dna repair]]
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[[Category: Glycosidase]]
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[[Category: Hydrolase-dna complex]]
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[[Category: Nucleus]]
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Current revision

Human Thymine DNA Glycosylase Bound to Substrate Analog 2'-fluoro-2'-deoxyuridine

PDB ID 3ufj

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