3oq0

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[[Image:3oq0.png|left|200px]]
 
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==Crystal Structure of motif N of Saccharomyces cerevisiae Dbf4==
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The line below this paragraph, containing "STRUCTURE_3oq0", creates the "Structure Box" on the page.
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<StructureSection load='3oq0' size='340' side='right'caption='[[3oq0]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3oq0]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OQ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OQ0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3oq0| PDB=3oq0 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oq0 OCA], [https://pdbe.org/3oq0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oq0 RCSB], [https://www.ebi.ac.uk/pdbsum/3oq0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oq0 ProSAT]</span></td></tr>
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</table>
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===Crystal Structure of motif N of Saccharomyces cerevisiae Dbf4===
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== Function ==
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[https://www.uniprot.org/uniprot/DBF4_YEAST DBF4_YEAST] Regulatory subunit of the CDC7-DBF4 kinase, also called DBF4-dependent kinase (DDK), which is involved in cell cycle regulation of premitotic and premeiotic chromosome replication and in chromosome segregation. DDK plays an essential role in initiating DNA replication at replication origins by phosphorylating the MCM2 and MCM4 subunits of the MCM2-7 helicase complex. DBF4 recruits the catalytic subunit CDC7 to MCM2 and to origins of replication. DDK has also postreplicative functions in meiosis. DDK phosphorylates the meiosis-specific double-strand break protein MER2 for initiation of meiotic recombination. Interacts with CDC5 during meiosis to promote double-strand breaks and monopolar spindle orientation. Inhibits CDC5 activity during mitosis through direct binding to its PBD.<ref>PMID:8066465</ref> <ref>PMID:12441400</ref> <ref>PMID:16319063</ref> <ref>PMID:17018296</ref> <ref>PMID:19013276</ref> <ref>PMID:18245450</ref> <ref>PMID:19692334</ref> <ref>PMID:19478884</ref> <ref>PMID:20436286</ref> <ref>PMID:21036905</ref> <ref>PMID:20170732</ref> <ref>PMID:20054399</ref>
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== References ==
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==About this Structure==
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<references/>
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[[3oq0]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OQ0 OCA].
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Duncker, B P.]]
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[[Category: Duncker BP]]
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[[Category: Guarne, A.]]
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[[Category: Guarne A]]
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[[Category: Jones, D R.]]
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[[Category: Jones DR]]
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[[Category: Matthews, L A.]]
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[[Category: Matthews LA]]
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[[Category: Prasad, A A.]]
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[[Category: Prasad AA]]
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[[Category: Brct]]
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[[Category: Cdc7]]
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[[Category: Cell cycle]]
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[[Category: Ddk]]
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[[Category: Fha domain]]
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[[Category: Nuclear]]
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[[Category: Phosphorylation]]
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[[Category: Rad53]]
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[[Category: Regulatory subunit of ddk]]
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[[Category: Replication checkpoint]]
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Current revision

Crystal Structure of motif N of Saccharomyces cerevisiae Dbf4

PDB ID 3oq0

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